Gold Nanocluster-Mediated Cellular Death under Electromagnetic Radiation.
This study investigated 2 nm protein-stabilized gold nanoclusters in six mammalian cell types under 1 GHz electromagnetic field exposure. The authors report low intrinsic toxicity of the nanoclusters, but a significant decrease in cell viability when nanocluster-incubated cells were exposed to the 1 GHz field, described as microwave-dependent cytotoxicity likely due to localized heating. In mice, nanoclusters were still present 24 hours after i.v. injection, and the authors suggest potential use as nanomedicines for cancer therapy.
Key points
- The work examines ultrasmall (2 nm) protein-stabilized gold nanoclusters in multiple mammalian cell types.
- Cellular association of the nanoclusters is reported to be concentration-dependent.
- Nanoclusters are described as having low intrinsic toxicity in vitro.
- Exposure of nanocluster-incubated cells to a 1 GHz electromagnetic field is reported to significantly reduce cell viability.
- The cytotoxicity is characterized as microwave-dependent and attributed to likely localized heating.
- After i.v. injection in mice, nanoclusters were still detectable at 24 hours post administration.
Referenced studies & papers
Relevant papers in OpenMel
Source:
Open original
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
Comments
Log in to comment.
No comments yet.