Synthesis, biological evaluation, molecular docking, molecular dynamics simulation, and ADME studies of novel carbazole-aniline hybrids as cytotoxic agents.
Research
RF Safe Research Library
Jan 1, 2026
This study reports the design and synthesis of seven carbazole-aniline hybrids and evaluates their cytotoxicity in breast (MCF-7) and colon (SW480) cancer cell lines. Compound 5e was identified as the most potent in vitro candidate and was supported by docking and molecular dynamics results suggesting binding to…
Mitigation of 3.5 GHz Electromagnetic Field-Induced BV2 Microglial Cytotoxicity by Polydeoxyribonucleotide
Research
RF Safe Research Library
Jan 1, 2025
This in vitro study exposed BV2 mouse microglial cells to 3.5 GHz EMF for 2 hours and reports reduced cell growth and increased apoptosis alongside oxidative stress and signaling changes. The authors report that ROS generation and activation of JNK-1/2 and p38 MAPK were key events in the observed cytotoxicity.…
Comparison of pulsed and continuous electromagnetic field generated by WPT system on human dermal and neural cells.
Research
RF Safe Research Library
Jan 1, 2024
This in vitro study tested electromagnetic fields generated by a prototype wireless power transfer (wireless charging) system on four human dermal and neural cell lines. Across pulsed and continuous exposure conditions, the authors report no negative effects on morphology/cytoskeleton, viability/mitosis,…
Impact of electromagnetic fields on in vitro toxicity of silver and graphene nanoparticles.
Research
RF Safe Research Library
Jan 1, 2019
This in vitro study examined whether RF electromagnetic fields (900, 2400, 7500 MHz) modify the toxicity of silver and graphene nanoparticles in human fibroblast cultures. The authors report EMF-associated changes in cytotoxicity and ROS that depended on nanoparticle type, shape, and concentration, with the strongest…
Genotoxic and cytotoxic effects of 50 Hz 1 mT electromagnetic field on larval rainbow trout (Oncorhynchus mykiss), Baltic clam (Limecola balthica) and common ragworm (Hediste diversicolor).
Research
RF Safe Research Library
Jan 1, 2019
This animal study assessed genotoxic and cytotoxic responses in aquatic species exposed to a 50 Hz, 1 mT electromagnetic field. Nuclear abnormality assays indicated significant increases in multiple genotoxicity endpoints across species, with the most pronounced effects in Baltic clam gill cells. Cytotoxicity…
Effects of electromagnetic field, cisplatin and morphine on cytotoxicity and expression levels of DNA repair genes.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study examined how morphine, a 50-Hz 0.50 mT electromagnetic field (intermittent), and cisplatin co-treatments affected DNA repair gene expression and cytotoxicity in MCF-7 and SH-SY5Y cells. Morphine alone was reported to down-regulate examined DNA repair genes, whereas morphine plus EMF did not…
Evaluation of Cytotoxic and Genotoxic Effects of Extremely Low-frequency Electromagnetic Field on Mesenchymal Stromal Cells.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study evaluated whether a therapeutic extremely low-frequency EMF exposure (5 Hz, 0.4 mT) causes cytotoxic or genotoxic effects in a human mesenchymal stromal cell line. Cells were exposed for 20 minutes per day, three times per week, for two weeks and assessed for viability, proliferation, and…
Electromagnetic Field Could Protect SH-SY5Y Cells Against Cisplatin Cytotoxicity, But Not MCF-7 Cells.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study exposed MCF-7 and SH-SY5Y cells to a 50 Hz, 0.50 mT electromagnetic field in combination with cisplatin and/or morphine. The combined "CDDP+Mor+EMF" condition showed higher cisplatin IC values than cisplatin alone and "CDDP+Mor" in both cell lines, consistent with reduced cisplatin cytotoxicity.…
Biodegradable, pH-sensitive chitosan beads obtained under microwave radiation for advanced cell culture.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study describes microwave-assisted, green-chemistry synthesis of pH-sensitive chitosan beads crosslinked with a glutamic acid/1,5-pentanodiol mixture and optionally modified with Tilia platyphyllos extract. The beads were characterized (FT-IR, SEM), tested for swelling, pH sensitivity, antioxidant…
Gold Nanocluster-Mediated Cellular Death under Electromagnetic Radiation.
Research
RF Safe Research Library
Jan 1, 2017
This study investigated 2 nm protein-stabilized gold nanoclusters in six mammalian cell types under 1 GHz electromagnetic field exposure. The authors report low intrinsic toxicity of the nanoclusters, but a significant decrease in cell viability when nanocluster-incubated cells were exposed to the 1 GHz field,…
Autophagy and enhanced chemosensitivity in experimental pancreatic cancers induced by noninvasive radiofrequency field treatment.
Research
RF Safe Research Library
Jan 1, 2014
This study tested noninvasive 13.56 MHz radiofrequency electric fields as a treatment adjunct for pancreatic ductal adenocarcinoma in cell lines and mouse xenograft models. The authors report RF exposure caused cytotoxicity in PDAC cells via autophagy (not apoptosis) and that normal pancreatic ductal epithelial cells…
Noninvasive radiofrequency field-induced hyperthermic cytotoxicity in human cancer cells using cetuximab-targeted gold nanoparticles.
Research
RF Safe Research Library
Jan 1, 2008
This in vitro study reports that shortwave (MHz-range) RF exposure can induce strong cytotoxicity in EGFR-overexpressing human cancer cells when those cells have internalized cetuximab-targeted gold nanoparticles. Control nanoparticles showed minimal uptake and substantially lower cytotoxicity under RF exposure. An…