Effects of a 50 Hz Electric Field on Brain Tissue and Blood Tissue

PAPER manual 2023 Animal study Effect: harm Evidence: Low

Read original paper → DOI: 10.3390/app13053276 Evidence Lab

Abstract

Effects of a 50 Hz Electric Field on Brain Tissue and Blood Tissue Şenol N, Kaya E, Coşkun Ö, Aslankoç R, Çömlekçi S. Evaluation of the Effects of a 50 Hz Electric Field on Brain Tissue by Immunohistochemical Method, and on Blood Tissue by Biochemical, Physiological and Comet Method. Applied Sciences. 2023; 13(5):3276. doi: 10.3390/app13053276 Abstract The aim of this study was to evaluate the possible effects of a 50 Hz electric field on brain tissue and the positive effects of juglone (5-hydroxy-1,4-naphthoquinone) antioxidant activity, using the immunohistochemical technique on male Wistar-Albino rats. The effects on blood tissue were also examined using biochemical, physiological and comet methods. Animals were randomly divided into three groups (eight in each group): group I: control, group II: electric field, group III: 50 Hz electric field + juglone (5-hydroxy-1,4-naphthoquinone)/300 ppm. Juglone was applied per day by gavage over 30 days. At the end of the experimental procedure, animals were sacrificed and brain tissue was subjected to routine histologic and immunohistochemical processes. As a result of histopathological examination, the brain tissue of rats with 50 Hz electric field exposure showed severe histopathological changes. The differences between groups were statistically significant according to total comet score (p = 0.001). For the antioxidant parameters on the blood, SOD activity in the electric field group was significantly higher among the other groups, although we did not find significant differences in MDA, CAT activity level. Open access paper: mdpi.com

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Male Wistar-Albino rats

Sample size

Exposure

ELF · 0.05 MHz · 30 days

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

Rats exposed to a 50 Hz electric field showed severe histopathological changes in brain tissue. Total comet score differed significantly between groups (p = 0.001). In blood antioxidant parameters, SOD activity was significantly higher in the electric field group, while no significant differences were found for MDA or CAT activity.

Outcomes measured

Brain histopathology (histologic/immunohistochemical assessment)
Blood antioxidant parameters (SOD, MDA, CAT)
Comet assay / total comet score (DNA damage)
Physiological measures (not specified)
Biochemical measures (not specified)

Limitations

Electric field exposure level/intensity not reported in the abstract
Specific immunohistochemical markers and brain regions not described in the abstract
Physiological and biochemical endpoints are not specified in the abstract
Animal study; generalizability to humans is uncertain

Suggested hubs

occupational-exposure (0.2)
Study involves 50 Hz electric field exposure (ELF), which can be relevant to power-frequency/occupational contexts, though no specific setting is stated.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "ELF",
        "source": null,
        "frequency_mhz": 0.05000000000000000277555756156289135105907917022705078125,
        "sar_wkg": null,
        "duration": "30 days"
    },
    "population": "Male Wistar-Albino rats",
    "sample_size": 24,
    "outcomes": [
        "Brain histopathology (histologic/immunohistochemical assessment)",
        "Blood antioxidant parameters (SOD, MDA, CAT)",
        "Comet assay / total comet score (DNA damage)",
        "Physiological measures (not specified)",
        "Biochemical measures (not specified)"
    ],
    "main_findings": "Rats exposed to a 50 Hz electric field showed severe histopathological changes in brain tissue. Total comet score differed significantly between groups (p = 0.001). In blood antioxidant parameters, SOD activity was significantly higher in the electric field group, while no significant differences were found for MDA or CAT activity.",
    "effect_direction": "harm",
    "limitations": [
        "Electric field exposure level/intensity not reported in the abstract",
        "Specific immunohistochemical markers and brain regions not described in the abstract",
        "Physiological and biochemical endpoints are not specified in the abstract",
        "Animal study; generalizability to humans is uncertain"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "50 Hz",
        "electric field",
        "ELF",
        "rat",
        "brain tissue",
        "blood",
        "immunohistochemistry",
        "histopathology",
        "comet assay",
        "DNA damage",
        "SOD",
        "MDA",
        "CAT",
        "juglone",
        "antioxidant"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.200000000000000011102230246251565404236316680908203125,
            "reason": "Study involves 50 Hz electric field exposure (ELF), which can be relevant to power-frequency/occupational contexts, though no specific setting is stated."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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