Impact of RFR on DNA damage & antioxidants in peripheral blood lymphocytes of humans residing in the vicinity of mobile phone base stations

Abstract

Impact of RFR on DNA damage & antioxidants in peripheral blood lymphocytes of humans residing in the vicinity of mobile phone base stations Zothansiama, Zosangzuali M, Lalramdinpuii M, Jagetia GC. Impact of radiofrequency radiation on DNA damage and antioxidants in peripheral blood lymphocytes of humans residing in the vicinity of mobile phone base stations. Electromagn Biol Med. 2017 Aug 4:1-11. doi: 10.1080/15368378.2017.1350584. Abstract Radiofrequency radiations (RFRs) emitted by mobile phone base stations have raised concerns on its adverse impact on humans residing in the vicinity of mobile phone base stations. Therefore, the present study was envisaged to evaluate the effect of RFR on the DNA damage and antioxidant status in cultured human peripheral blood lymphocytes (HPBLs) of individuals residing in the vicinity of mobile phone base stations and comparing it with healthy controls. The study groups matched for various demographic data including age, gender, dietary pattern, smoking habit, alcohol consumption, duration of mobile phone use and average daily mobile phone use. The RF power density of the exposed individuals was significantly higher (p < 0.0001) when compared to the control group. The HPBLs were cultured and the DNA damage was assessed by cytokinesis blocked micronucleus (MN) assay in the binucleate lymphocytes. The analyses of data from the exposed group (n = 40), residing within a perimeter of 80 meters of mobile base stations, showed significantly (p < 0.0001) higher frequency of micronuclei (MN) when compared to the control group, residing 300 meters away from the mobile base station/s. The analysis of various antioxidants in the plasma of exposed individuals revealed a significant attrition in glutathione (GSH) concentration (p < 0.01), activities of catalase (CAT) (p < 0.001) and superoxide dismutase (SOD) (p < 0.001) and rise in lipid peroxidation (LOO) when compared to controls. Multiple linear regression analyses revealed a significant association among reduced GSH concentration (p < 0.05), CAT (p < 0.001) and SOD (p < 0.001) activities and elevated MN frequency (p < 0.001) and LOO (p < 0.001) with increasing RF power density. ncbi.nlm.nih.gov My note: All of the recorded RFR power density values in this study were well below the Federal Communication Commission's maximum permissible exposure limits in the U.S. for the general population. These limits are are 6,000 mW/m2 [milliwatts per square meter] for 900 MHz and 10,000 mW/m2 for 1800 MHz radiofrequency radiation. In contrast, the highest recorded value in this study was 7.52 mW/m2 of RFR. The "exposed individuals" who resided within 80 meters of a cell antenna received an average of 5.00 mW/m2 of RFR in their bedrooms. To see excerpts from this study and related research: Cell Tower Health Effects or bit.ly

AI evidence extraction

Main findings

Individuals residing within 80 m of mobile base stations (n=40) had significantly higher RF power density than controls residing 300 m away, and showed significantly higher micronucleus frequency in cultured peripheral blood lymphocytes. Exposed individuals also had lower GSH and reduced CAT and SOD activities, with higher lipid peroxidation; regression analyses reported associations between increasing RF power density and higher micronucleus frequency and lipid peroxidation and lower antioxidant measures.

Outcomes measured

• RF power density (exposure assessment)
• DNA damage (micronucleus frequency in cytokinesis-blocked micronucleus assay)
• Plasma antioxidants: glutathione (GSH), catalase (CAT), superoxide dismutase (SOD)
• Lipid peroxidation (LOO)

Limitations

• Frequency band(s) not reported in abstract
• Exposure metric reported as RF power density; measurement methods and timing not described in abstract
• Control group size not stated in abstract
• Observational design; residual confounding cannot be excluded based on abstract

Suggested hubs

• occupational-exposure (0)

{
    "study_type": "case_control",
    "exposure": {
        "band": "RF",
        "source": "mobile phone base station",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Humans residing in the vicinity of mobile phone base stations; peripheral blood lymphocytes assessed",
    "sample_size": 40,
    "outcomes": [
        "RF power density (exposure assessment)",
        "DNA damage (micronucleus frequency in cytokinesis-blocked micronucleus assay)",
        "Plasma antioxidants: glutathione (GSH), catalase (CAT), superoxide dismutase (SOD)",
        "Lipid peroxidation (LOO)"
    ],
    "main_findings": "Individuals residing within 80 m of mobile base stations (n=40) had significantly higher RF power density than controls residing 300 m away, and showed significantly higher micronucleus frequency in cultured peripheral blood lymphocytes. Exposed individuals also had lower GSH and reduced CAT and SOD activities, with higher lipid peroxidation; regression analyses reported associations between increasing RF power density and higher micronucleus frequency and lipid peroxidation and lower antioxidant measures.",
    "effect_direction": "harm",
    "limitations": [
        "Frequency band(s) not reported in abstract",
        "Exposure metric reported as RF power density; measurement methods and timing not described in abstract",
        "Control group size not stated in abstract",
        "Observational design; residual confounding cannot be excluded based on abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "radiofrequency radiation",
        "base station",
        "cell tower",
        "power density",
        "micronucleus assay",
        "DNA damage",
        "oxidative stress",
        "glutathione",
        "catalase",
        "superoxide dismutase",
        "lipid peroxidation"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0,
            "reason": null
        }
    ]
}

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