Upregulation of specific mRNA levels in rat brain after cell phone exposure.

Abstract

Adult Sprague-Dawley rats were exposed to regular cell phones for 6 h per day for 126 days (18 weeks). RT-PCR was used to investigate the changes in levels of mRNA synthesis of several injury-associated proteins. Calcium ATPase, Neural Cell Adhesion Molecule, Neural Growth Factor, and Vascular Endothelial Growth Factor were evaluated. The results showed statistically significant mRNA up-regulation of these proteins in the brains of rats exposed to cell phone radiation. These results indicate that relative chronic exposure to cell phone microwave radiation may result in cumulative injuries that could eventually lead to clinically significant neurological damage.

AI evidence extraction

Main findings

Rats exposed to regular cell phones for 6 h/day over 18 weeks showed statistically significant up-regulation of mRNA levels for Calcium ATPase, Neural Cell Adhesion Molecule, Neural Growth Factor, and Vascular Endothelial Growth Factor in brain tissue.

Outcomes measured

• Brain mRNA levels (RT-PCR) of Calcium ATPase
• Brain mRNA levels (RT-PCR) of Neural Cell Adhesion Molecule (NCAM)
• Brain mRNA levels (RT-PCR) of Neural Growth Factor (NGF)
• Brain mRNA levels (RT-PCR) of Vascular Endothelial Growth Factor (VEGF)

Limitations

• Frequency and SAR/exposure metrics not reported in the abstract
• Sample size not reported in the abstract
• Only mRNA expression endpoints reported; no direct clinical/functional neurological outcomes described in the abstract
• Exposure described as 'regular cell phones' without further characterization

Suggested hubs

• mobile-phones (0.9)
  Exposure source is regular cell phones.

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": "mobile phone",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "6 h/day for 126 days (18 weeks)"
    },
    "population": "Adult Sprague-Dawley rats",
    "sample_size": null,
    "outcomes": [
        "Brain mRNA levels (RT-PCR) of Calcium ATPase",
        "Brain mRNA levels (RT-PCR) of Neural Cell Adhesion Molecule (NCAM)",
        "Brain mRNA levels (RT-PCR) of Neural Growth Factor (NGF)",
        "Brain mRNA levels (RT-PCR) of Vascular Endothelial Growth Factor (VEGF)"
    ],
    "main_findings": "Rats exposed to regular cell phones for 6 h/day over 18 weeks showed statistically significant up-regulation of mRNA levels for Calcium ATPase, Neural Cell Adhesion Molecule, Neural Growth Factor, and Vascular Endothelial Growth Factor in brain tissue.",
    "effect_direction": "harm",
    "limitations": [
        "Frequency and SAR/exposure metrics not reported in the abstract",
        "Sample size not reported in the abstract",
        "Only mRNA expression endpoints reported; no direct clinical/functional neurological outcomes described in the abstract",
        "Exposure described as 'regular cell phones' without further characterization"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "rat",
        "Sprague-Dawley",
        "mobile phone",
        "microwave radiation",
        "chronic exposure",
        "brain",
        "RT-PCR",
        "mRNA upregulation",
        "Calcium ATPase",
        "Neural Cell Adhesion Molecule",
        "Neural Growth Factor",
        "Vascular Endothelial Growth Factor"
    ],
    "suggested_hubs": [
        {
            "slug": "mobile-phones",
            "weight": 0.90000000000000002220446049250313080847263336181640625,
            "reason": "Exposure source is regular cell phones."
        }
    ]
}

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