Single strand DNA breaks in rat brain cells exposed to microwave radiation.

PAPER pubmed Mutation research 2006 Animal study Effect: harm Evidence: Low

Read original paper → DOI: 10.1016/j.mrfmmm.2005.12.006 PMID: 16458332 Evidence Lab

Abstract

This investigation concerns with the effect of low intensity microwave (2.45 and 16.5 GHz, SAR 1.0 and 2.01 W/kg, respectively) radiation on developing rat brain. Wistar rats (35 days old, male, six rats in each group) were selected for this study. These animals were exposed for 35 days at the above mentioned frequencies separately in two different exposure systems. After the exposure period, the rats were sacrificed and the whole brain tissue was dissected and used for study of single strand DNA breaks by micro gel electrophoresis (comet assay). Single strand DNA breaks were measured as tail length of comet. Fifty cells from each slide and two slides per animal were observed. One-way ANOVA method was adopted for statistical analysis. This study shows that the chronic exposure to these radiations cause statistically significant (p<0.001) increase in DNA single strand breaks in brain cells of rat.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Male Wistar rats, 35 days old

Sample size

Exposure

microwave · 35 days (chronic exposure)

Evidence strength

Low

Confidence: 86% · Peer-reviewed: yes

Main findings

Male Wistar rats exposed for 35 days to low-intensity microwave radiation at 2.45 GHz (SAR 1.0 W/kg) or 16.5 GHz (SAR 2.01 W/kg) showed a statistically significant increase (p<0.001) in DNA single strand breaks in brain cells compared with controls, measured by comet assay tail length.

Outcomes measured

Single strand DNA breaks in brain cells (comet assay tail length)

Limitations

Exposure source and detailed exposure conditions beyond frequency and SAR are not described in the abstract.
Only male rats were studied.
Small group size (six rats per group).
Outcome limited to comet assay tail length in whole brain tissue; no other biological/functional endpoints reported.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "35 days (chronic exposure)"
    },
    "population": "Male Wistar rats, 35 days old",
    "sample_size": 12,
    "outcomes": [
        "Single strand DNA breaks in brain cells (comet assay tail length)"
    ],
    "main_findings": "Male Wistar rats exposed for 35 days to low-intensity microwave radiation at 2.45 GHz (SAR 1.0 W/kg) or 16.5 GHz (SAR 2.01 W/kg) showed a statistically significant increase (p<0.001) in DNA single strand breaks in brain cells compared with controls, measured by comet assay tail length.",
    "effect_direction": "harm",
    "limitations": [
        "Exposure source and detailed exposure conditions beyond frequency and SAR are not described in the abstract.",
        "Only male rats were studied.",
        "Small group size (six rats per group).",
        "Outcome limited to comet assay tail length in whole brain tissue; no other biological/functional endpoints reported."
    ],
    "evidence_strength": "low",
    "confidence": 0.85999999999999998667732370449812151491641998291015625,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "2.45 GHz",
        "16.5 GHz",
        "SAR",
        "rat brain",
        "DNA damage",
        "single strand breaks",
        "comet assay",
        "chronic exposure"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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