Cytological effects of microwave radiation in Chinese hamster cells in vitro.

PAPER pubmed Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie 1978 In vitro study Effect: mixed Evidence: Low

Read original paper → DOI: 10.1139/g78-004 PMID: 657002 Evidence Lab

Abstract

Cytological effects were investigated in the Chinese hamster cell line (CHO-K1) exposed to microwave radiation of 2450 MHz frequency and incident power of 25 to 200 W for a period of 30 min. Nuclear vacuoles, pycnotic and decondensed chromosomes were observed in cells exposed to 25 W under elevated temperature conditions (uncontrolled temp). In addition a significant increase in chromosomal breakages/cell was observed. Cells exposed to relatively higher power, 75-200 W, under hypothermic conditions (29 degrees C) revealed no significant increase in either nuclear vacuoles or other chromosomal anomalies over control cells. Radiation-induced temperature elevation appears to be an essential factor in the cytological effects of microwave.

AI evidence extraction

At a glance

Study type

In vitro study

Effect direction

mixed

Population

Chinese hamster cell line (CHO-K1)

Sample size

—

Exposure

microwave · 2450 MHz · 30 min

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

CHO-K1 cells exposed to 2450 MHz microwaves at 25 W under elevated (uncontrolled) temperature conditions showed nuclear vacuoles, pycnotic and decondensed chromosomes, and a significant increase in chromosomal breakages per cell. Cells exposed at higher incident power (75–200 W) under hypothermic conditions (29°C) showed no significant increase in nuclear vacuoles or other chromosomal anomalies versus controls. The authors state that radiation-induced temperature elevation appears essential for the observed cytological effects.

Outcomes measured

nuclear vacuoles
pycnotic chromosomes
decondensed chromosomes
chromosomal breakages per cell
chromosomal anomalies (overall)

Limitations

Temperature was uncontrolled in the 25 W exposure condition (elevated temperature).
No sample size reported in the abstract.
Dosimetry beyond incident power (e.g., SAR) not reported in the abstract.

Suggested hubs

thermal-effects (0.7)
Findings are explicitly linked to radiation-induced temperature elevation and comparison of elevated vs hypothermic conditions.

View raw extracted JSON

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 2450,
        "sar_wkg": null,
        "duration": "30 min"
    },
    "population": "Chinese hamster cell line (CHO-K1)",
    "sample_size": null,
    "outcomes": [
        "nuclear vacuoles",
        "pycnotic chromosomes",
        "decondensed chromosomes",
        "chromosomal breakages per cell",
        "chromosomal anomalies (overall)"
    ],
    "main_findings": "CHO-K1 cells exposed to 2450 MHz microwaves at 25 W under elevated (uncontrolled) temperature conditions showed nuclear vacuoles, pycnotic and decondensed chromosomes, and a significant increase in chromosomal breakages per cell. Cells exposed at higher incident power (75–200 W) under hypothermic conditions (29°C) showed no significant increase in nuclear vacuoles or other chromosomal anomalies versus controls. The authors state that radiation-induced temperature elevation appears essential for the observed cytological effects.",
    "effect_direction": "mixed",
    "limitations": [
        "Temperature was uncontrolled in the 25 W exposure condition (elevated temperature).",
        "No sample size reported in the abstract.",
        "Dosimetry beyond incident power (e.g., SAR) not reported in the abstract."
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "2450 MHz",
        "in vitro",
        "CHO-K1",
        "Chinese hamster cells",
        "chromosomal breakage",
        "cytological effects",
        "temperature",
        "thermal effects"
    ],
    "suggested_hubs": [
        {
            "slug": "thermal-effects",
            "weight": 0.6999999999999999555910790149937383830547332763671875,
            "reason": "Findings are explicitly linked to radiation-induced temperature elevation and comparison of elevated vs hypothermic conditions."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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