Cytological effects of 50 Hz electromagnetic fields on human lymphocytes in vitro.

PAPER pubmed Mutation research 1995 In vitro study Effect: mixed Evidence: Low

Read original paper → DOI: 10.1016/0165-7992(95)90047-0 PMID: 7700279 Evidence Lab

Abstract

Incubation of human peripheral blood cultures in the presence of an electromagnetic field (EMF) of 50 Hz and 5 mT leads to stimulation of the cell cycle of dividing lymphocytes but has no influence on the frequencies of sister-chromatid exchanges. Comparative studies with two different exposure systems and with different culture temperatures indicate that the effect on the cell cycle results from the EMF and is not a thermal effect. These data support the assumption that with respect to their suspected carcinogenic effects EMFs have no initiating but probably promoting effects.

AI evidence extraction

At a glance

Study type

In vitro study

Effect direction

mixed

Population

Human peripheral blood lymphocytes (in vitro cultures)

Sample size

—

Exposure

ELF · 0.05 MHz

Evidence strength

Low

Confidence: 74% · Peer-reviewed: yes

Main findings

Exposure of human peripheral blood cultures to a 50 Hz, 5 mT electromagnetic field stimulated the cell cycle of dividing lymphocytes but did not change sister-chromatid exchange frequencies. Comparative tests with different exposure systems and culture temperatures suggested the cell-cycle effect was due to EMF rather than heating.

Outcomes measured

Cell cycle stimulation in dividing lymphocytes
Sister-chromatid exchange (SCE) frequency

Limitations

In vitro study (human lymphocyte cultures)
Sample size not reported in abstract
Exposure duration not reported in abstract
Carcinogenic implications are interpretive and not directly measured

Suggested hubs

occupational-exposure (0.25)
Study examines ELF (50 Hz) magnetic field exposure relevant to power-frequency environments, though no specific occupational setting is stated.

View raw extracted JSON

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "ELF",
        "source": null,
        "frequency_mhz": 0.05000000000000000277555756156289135105907917022705078125,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Human peripheral blood lymphocytes (in vitro cultures)",
    "sample_size": null,
    "outcomes": [
        "Cell cycle stimulation in dividing lymphocytes",
        "Sister-chromatid exchange (SCE) frequency"
    ],
    "main_findings": "Exposure of human peripheral blood cultures to a 50 Hz, 5 mT electromagnetic field stimulated the cell cycle of dividing lymphocytes but did not change sister-chromatid exchange frequencies. Comparative tests with different exposure systems and culture temperatures suggested the cell-cycle effect was due to EMF rather than heating.",
    "effect_direction": "mixed",
    "limitations": [
        "In vitro study (human lymphocyte cultures)",
        "Sample size not reported in abstract",
        "Exposure duration not reported in abstract",
        "Carcinogenic implications are interpretive and not directly measured"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "50 Hz",
        "ELF-EMF",
        "5 mT",
        "human lymphocytes",
        "in vitro",
        "cell cycle",
        "sister-chromatid exchanges",
        "thermal effects"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.25,
            "reason": "Study examines ELF (50 Hz) magnetic field exposure relevant to power-frequency environments, though no specific occupational setting is stated."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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