[Effects of extremely low frequency electromagnetic fields on apoptosis and cell cycle of mouse brain and liver cells].

PAPER pubmed Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2003 Animal study Effect: harm Evidence: Low

Read original paper → PMID: 14761394 Evidence Lab

Abstract

OBJECTIVE: To study the effects of extremely low frequency electromagnetic fields (ELF EMFs) on apoptosis and cell cycle of mouse brain and liver cells. METHODS: Mice were exposed to 50 Hz, 0.2 mT or 6.0 mT electromagnetic fields for 2 weeks. TUNEL and flow cytometric methods were used to analyze apoptosis and cell cycle of brain and liver cells. RESULTS: After exposure to 0.2 mT and 6.0 mT ELF EMFs for 2 weeks, apoptosis rates of brain cells [(5.60 +/- 1.47)% and (4.73 +/- 0.48)% respectively] were higher than that of control [(2.90 +/- 0.75)%], and apoptosis rates of liver cells [(4.19 +/- 2.08)% and (3.38 +/- 0.65)% respectively] were higher than that of control [(1.84 +/- 0.76)%]. G0/G1 cell percentage of brain cells [(80.21 +/- 1.68)% and (79.54 +/- 0.56)% respectively] were higher than that of control [(76.85 +/- 0.83)%], and those of liver cells [(79.42 +/- 1.80)% and (80.47 +/- 1.79)% respectively] were higher than that of control [(73.36 +/- 3.10)%]. The above differences were all statistically significant as P < 0.05. At the same time S and G2 + M cell percentage of brain and liver cells were significantly decreased. CONCLUSION: Exposure to 50 Hz EMFs may alter cell cycle and induce apoptosis of mouse brain and liver cells.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Mice (mouse brain and liver cells)

Sample size

—

Exposure

ELF · 5.0E-5 MHz · 2 weeks

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

Mice exposed to 50 Hz electromagnetic fields at 0.2 mT or 6.0 mT for 2 weeks had higher apoptosis rates in brain and liver cells than controls, with statistically significant differences (P<0.05). Exposed mice also showed increased G0/G1 cell percentages and decreased S and G2+M percentages in brain and liver cells versus controls (P<0.05).

Outcomes measured

Apoptosis (TUNEL; flow cytometry)
Cell cycle distribution (G0/G1, S, G2+M; flow cytometry)

Limitations

Sample size not reported in abstract
Limited exposure durations assessed (2 weeks only)
Only two field intensities tested (0.2 mT and 6.0 mT)
Outcomes limited to apoptosis and cell-cycle measures in brain and liver cells

Suggested hubs

occupational-exposure (0.35)
Published in an industrial hygiene/occupational diseases journal and involves ELF field exposure relevant to occupational settings.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "ELF",
        "source": null,
        "frequency_mhz": 5.00000000000000023960868011929647991564706899225711822509765625e-5,
        "sar_wkg": null,
        "duration": "2 weeks"
    },
    "population": "Mice (mouse brain and liver cells)",
    "sample_size": null,
    "outcomes": [
        "Apoptosis (TUNEL; flow cytometry)",
        "Cell cycle distribution (G0/G1, S, G2+M; flow cytometry)"
    ],
    "main_findings": "Mice exposed to 50 Hz electromagnetic fields at 0.2 mT or 6.0 mT for 2 weeks had higher apoptosis rates in brain and liver cells than controls, with statistically significant differences (P<0.05). Exposed mice also showed increased G0/G1 cell percentages and decreased S and G2+M percentages in brain and liver cells versus controls (P<0.05).",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in abstract",
        "Limited exposure durations assessed (2 weeks only)",
        "Only two field intensities tested (0.2 mT and 6.0 mT)",
        "Outcomes limited to apoptosis and cell-cycle measures in brain and liver cells"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "extremely low frequency",
        "ELF EMF",
        "50 Hz",
        "0.2 mT",
        "6.0 mT",
        "mouse",
        "brain cells",
        "liver cells",
        "apoptosis",
        "TUNEL",
        "flow cytometry",
        "cell cycle",
        "G0/G1",
        "S phase",
        "G2/M"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.34999999999999997779553950749686919152736663818359375,
            "reason": "Published in an industrial hygiene/occupational diseases journal and involves ELF field exposure relevant to occupational settings."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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