The role of digital device use on the risk of migraine: a univariable and multivariable Mendelian

Abstract

The role of digital device use on the risk of migraine: a univariable and multivariable Mendelian randomization study He Z, Qiu F, Yang J, Zhao M. The role of digital device use on the risk of migraine: a univariable and multivariable Mendelian randomization study. Front Neurol. 2024 Oct 30;15:1462414. doi: 10.3389/fneur.2024.1462414. Abstract Background: The pervasive integration of digital devices into daily life has raised concerns about their potential health impacts. This study aimed to explore the causal relationships between digital device use and the risk of migraine using Mendelian randomization (MR). Methods: Genetic data on digital device use and migraines were sourced from large-scale genome-wide association studies conducted by the UK Biobank, the FinnGen study, and the International Headache Genetics Consortium. Univariable MR (UVMR), meta-analysis, and multivariable MR (MVMR) approaches were conducted to explore and verify the causal effects of digital device use (including mobile phone use, computer use, playing computer games, and watching television) on migraine risk. Sensitivity analyses were conducted using Cochran's Q, MR-Egger intercept test, MR pleiotropy residual sum and outlier, MR Radial, MR Steiger, and leave-one-out methods. Results: UVMR analyses revealed that genetically predicted mobile phone use was significantly associated with an increased risk of overall migraine (odds ratio [OR] = 2.39, p = 9.78e-5) and migraine without aura (MO) (OR = 2.25, p = 0.024). Additionally, there were significant positive associations between genetically predicted television watching and the risk of overall migraine (OR = 1.63, p = 2.12e- 5) and MO (OR = 2.10, p = 4.98e-5). These results were further supported by the meta-analysis and MVMR analysis. Sensitivity analysis indicated no heterogeneity or pleiotropy. Conclusion: This comprehensive MR study provides preliminary evidence for the causal impact of mobile phone use and television watching on the risk of migraines. Further studies are needed to explore these associations across different populations. Open access paper: frontiersin.org

AI evidence extraction

Main findings

Using Mendelian randomization with GWAS data, genetically predicted mobile phone use was associated with increased risk of overall migraine (OR=2.39, p=9.78e-5) and migraine without aura (OR=2.25, p=0.024). Genetically predicted television watching was also positively associated with overall migraine (OR=1.63, p=2.12e-5) and migraine without aura (OR=2.10, p=4.98e-5); results were supported by meta-analysis and multivariable MR, with sensitivity analyses indicating no heterogeneity or pleiotropy.

Outcomes measured

• overall migraine
• migraine without aura (MO)

Limitations

• Frequency/band/SAR or other EMF exposure metrics were not reported; exposure was digital device use as a behavioral trait.
• Population characteristics and sample sizes were not provided in the abstract.
• Authors describe the evidence as preliminary and note need for studies in other populations.

{
    "study_type": "other",
    "exposure": {
        "band": null,
        "source": "mobile phone, television, computer, computer games (digital device use)",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": null,
    "sample_size": null,
    "outcomes": [
        "overall migraine",
        "migraine without aura (MO)"
    ],
    "main_findings": "Using Mendelian randomization with GWAS data, genetically predicted mobile phone use was associated with increased risk of overall migraine (OR=2.39, p=9.78e-5) and migraine without aura (OR=2.25, p=0.024). Genetically predicted television watching was also positively associated with overall migraine (OR=1.63, p=2.12e-5) and migraine without aura (OR=2.10, p=4.98e-5); results were supported by meta-analysis and multivariable MR, with sensitivity analyses indicating no heterogeneity or pleiotropy.",
    "effect_direction": "harm",
    "limitations": [
        "Frequency/band/SAR or other EMF exposure metrics were not reported; exposure was digital device use as a behavioral trait.",
        "Population characteristics and sample sizes were not provided in the abstract.",
        "Authors describe the evidence as preliminary and note need for studies in other populations."
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "Mendelian randomization",
        "GWAS",
        "UK Biobank",
        "FinnGen",
        "International Headache Genetics Consortium",
        "mobile phone use",
        "television watching",
        "digital device use",
        "migraine",
        "migraine without aura"
    ],
    "suggested_hubs": []
}

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