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Bidirectional Effect of Repeated Exposure to Extremely Low-Frequency Electromagnetic Field (50 Hz) of 1 and 7 mT on Oxidative/Antioxidative Status in Rat's Brain: The Prediction for the Vulnerability to Diseases.

Research RF Safe Research Library Jan 1, 2022

This rat study examined repeated 50 Hz ELF-EMF exposure (1 or 7 mT) and measured oxidative stress and antioxidant defense markers in the prefrontal cortex, including responses to a subsequent open-field stressor. The authors report intensity- and repetition-dependent effects: 1 mT produced weak changes and was…

Cardiac Cell Exposure to Electromagnetic Fields: Focus on Oxdative Stress and Apoptosis.

Research RF Safe Research Library Jan 1, 2022

This study assessed whether 915 MHz RF-EMF exposure alters oxidative stress and apoptosis markers in cardiac cells and mouse heart tissue. The authors report no statistically significant differences in apoptotic profile, antioxidant capacity, tissue integrity, or expression of apoptosis/antioxidant genes after…

Conformational changes of β-thalassemia major hemoglobin and oxidative status of plasma after in vitro exposure to extremely low-frequency electromagnetic fields: An artificial neural network analysis.

Research RF Safe Research Library Jan 1, 2021

This in vitro study exposed blood samples from β-thalassemia major patients and matched healthy donors (n=12 each) to 50 Hz ELF-EMF at 0.5 and 1 mT for 1–2 hours. The authors report that two-hour exposure induced significant oxidative changes in β-thalassemia major samples and examined protein/Hb structural features…

Comparing the Effects of Long-term Exposure to Extremely Low-frequency Electromagnetic Fields With Different Values on Learning, Memory, Anxiety, and β-amyloid Deposition in Adult Rats.

Research RF Safe Research Library Jan 1, 2021

This animal study exposed adult male rats to 50 Hz ELF-EMF at 1, 100, 500, or 2000 μT for 1 hour/day over two months and assessed behavior and brain markers. The authors report increased memory retention (higher step-through latency) alongside increased anxiety-like behavior (reduced open-arm entries), particularly…

Effects induced by a 50 Hz electromagnetic field and doxorubicin on Walker-256 carcinosarcoma growth and hepatic redox state in rats.

Research RF Safe Research Library Jan 1, 2021

This animal study compared 50 Hz extremely low-frequency EMF exposure with doxorubicin (and their combination) in Walker-256 carcinosarcoma-bearing rats, assessing tumor growth and liver redox-related outcomes. DOX and DOX+EMF were reported to inhibit tumor growth more than EMF alone, though EMF alone also showed an…

The guardians of germ cells; Sertoli-derived exosomes against electromagnetic field-induced oxidative stress in mouse spermatogonial stem cells.

Research RF Safe Research Library Jan 1, 2021

This in vitro study exposed mouse spermatogonial stem cells to 50 Hz EMF (2.5 mT; 1 h/day for 5 days) and assessed oxidative stress and cell health outcomes. The authors report increased ROS and apoptosis with reduced antioxidant (catalase) expression, viability, and colonization after EMF exposure. Sertoli…

Activation of matrix metalloproteinases and FoxO3a in HaCaT keratinocytes by radiofrequency electromagnetic field exposure.

Research RF Safe Research Library Jan 1, 2021

This in vitro study exposed HaCaT human keratinocytes to 1760 MHz RF-EMF (SAR 4.0 W/kg; 2 h/day for 4 days). The authors report increased intracellular ROS and increased expression/activity of several matrix metalloproteinases, along with increased phosphorylation of FoxO3a and ERK1/2. Cell growth/viability and…

Evaluation of the neuroprotective effects of Vitamin E on the rat substantia nigra neural cells exposed to electromagnetic field: An ultrastructural study.

Research RF Safe Research Library Jan 1, 2021

This rat study exposed animals to a 50 Hz, 3 mT electromagnetic field and assessed oxidative stress markers and substantia nigra ultrastructure. EMF exposure was associated with higher lipid peroxidation (MDA), lower SOD activity, and TEM-detected changes in nucleus/nuclear membrane and myelin sheath. Vitamin E…

Electromagnetic Fields Ameliorate Insulin Resistance and Hepatic Steatosis by Modulating Redox Homeostasis and SREBP-1c Expression in db/db Mice.

Research RF Safe Research Library Jan 1, 2021

This animal study examined whether 8 weeks of EMF exposure affects insulin resistance and fatty liver features in db/db mice. The authors report improvements in insulin resistance markers, hepatic redox balance, and steatosis-related outcomes after EMF exposure. They also report reduced liver triglycerides and lower…

Short ELF-EMF Exposure Targets SIRT1/Nrf2/HO-1 Signaling in THP-1 Cells.

Research RF Safe Research Library Jan 1, 2020

This in vitro study examined 50 Hz, 1 mT ELF-EMF exposure in LPS-treated THP-1 cells for 1–24 hours. The authors report increased HO-1 expression and Nrf2-related signaling, with nuclear enrichment of HO-1 and modulation of SIRT1/NF-κB pathways. They interpret these molecular changes as suggesting a protective,…

Enhancement in the ATP level and antioxidant capacity of under continuous exposure to extremely low-frequency electromagnetic field for multiple generations.

Research RF Safe Research Library Jan 1, 2020

This multi-generation animal study exposed worms continuously to 50 Hz, 3 mT extremely low-frequency electromagnetic fields and assessed outcomes in the 15th generation. The study reports increased body length, higher ATP content and ATP synthase activity, and upregulated ATP-related gene expression in exposed worms.…

Assessment of function, histopathological changes, and oxidative stress in liver tissue due to ionizing and non-ionizing radiations.

Research RF Safe Research Library Jan 1, 2020

This animal study evaluated liver function, histopathology, and oxidative stress markers after exposure to RF-EMF (900/1800 MHz and 2.4 GHz), x-rays (10 cGy or 8 Gy), and combinations including RF-EMF pre-exposure. Some liver enzymes (AST, ALT, ALP) showed some association with irradiation, while…

Effects of pulse-modulated radiofrequency magnetic field (RF-EMF) exposure on apoptosis, autophagy, oxidative stress and electron chain transport function in human neuroblastoma and murine microglial cells.

Research RF Safe Research Library Jan 1, 2020

This in vitro study exposed murine microglial (N9) and human neuroblastoma (SH-SY5Y) cells to ELF-modulated 935 MHz RF-EMF at 4 W/kg for 2 or 24 hours. The authors report no changes in apoptosis, cell viability, or AIF across conditions. They report increased ATG5 after 24 hours and a transient glutathione increase…

Antimicrobial activity of rosemary leaf extracts and efficacy of ethanol extract against testicular damage caused by 50-Hz electromagnetic field in albino rats.

Research RF Safe Research Library Jan 1, 2020

This animal study exposed male albino rats to a 50 Hz electromagnetic field for 2 or 4 hours and assessed reproductive hormones, oxidative stress markers, and testicular histology after 30 days. The abstract reports that EMF exposure reduced serum FSH, testosterone, and LH and catalase activity, while increasing…

Immune response of mollusk Onchidium struma to extremely low-frequency electromagnetic fields (ELF-EMF, 50 Hz) exposure based on immune-related enzyme activity and De novo transcriptome analysis.

Research RF Safe Research Library Jan 1, 2020

This animal study exposed the mollusk Onchidium struma to 50 Hz ELF-EMF at 100 μT or 500 μT for up to one week and assessed immune-related cell counts, enzyme activities, and transcriptomic changes. The 100 μT group showed increased total coelomocyte and spherulocyte density versus control and 500 μT, while some cell…

Impact of electromagnetic fields on in vitro toxicity of silver and graphene nanoparticles.

Research RF Safe Research Library Jan 1, 2019

This in vitro study examined whether RF electromagnetic fields (900, 2400, 7500 MHz) modify the toxicity of silver and graphene nanoparticles in human fibroblast cultures. The authors report EMF-associated changes in cytotoxicity and ROS that depended on nanoparticle type, shape, and concentration, with the strongest…

Altered morphology and biochemistry of the female rat liver following 900 megahertz electromagnetic field exposure during mid to late adolescence.

Research RF Safe Research Library Jan 1, 2019

This animal study examined whether 900 MHz EMF exposure during mid to late adolescence affects the liver in female rats. Compared with control and sham groups, the exposed group showed occasional liver histopathological irregularities. The exposed group also had significantly decreased 8-OHdG and SOD levels, and the…

Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients.

Research RF Safe Research Library Jan 1, 2018

This study evaluated whether adding extremely low frequency electromagnetic field (ELF-EMF) therapy to standard physical therapy modulates antioxidant gene expression in post-stroke patients. Forty-eight patients were split into an ELF-EMF group and a non-ELF-EMF group, with both groups receiving the same physical…

Impact of Long-Term RF-EMF on Oxidative Stress and Neuroinflammation in Aging Brains of C57BL/6 Mice.

Research RF Safe Research Library Jan 1, 2018

This animal study exposed 14-month-old C57BL/6 mice to 1950 MHz RF-EMF (SAR 5 W/kg) for 8 months. The authors report that aging was associated with increased oxidative damage, DNA damage, apoptosis, and glial activation markers in brain tissue. Long-term RF-EMF exposure did not change these markers in aged mice and…

Extremely low frequency electromagnetic field reduces oxidative stress during the rehabilitation of post-acute stroke patients.

Research RF Safe Research Library Jan 1, 2018

This study evaluated ELF-EMF magnetotherapy as an adjunct to post-acute ischemic stroke rehabilitation in 57 patients, comparing those who received ELF-EMF therapy with those who did not. The authors report that oxidative stress markers (TBARS, thiol, and carbonyl groups) decreased more in the ELF-EMF group than in…

A 60 Hz uniform electromagnetic field promotes human cell proliferation by decreasing intracellular reactive oxygen species levels.

Research RF Safe Research Library Jan 1, 2018

This in vitro study examined effects of a 6 mT, 60 Hz uniform ELF electromagnetic field on HeLa cells and primary IMR-90 fibroblasts. Single or repetitive exposure did not induce DNA damage or change viability, but continuous exposure over 168 hours was reported to increase proliferation in both cell types in a…

Effects of 900-MHz electromagnetic fields exposure throughout middle/late adolescence on the kidney morphology and biochemistry of the female rat.

Research RF Safe Research Library Jan 1, 2018

This animal study examined kidney effects in female rats exposed to continuous 900 MHz EMF for 1 hour daily during postnatal days 35–59. The authors report multiple histopathological alterations in kidneys of the EMF-exposed group, while control and sham groups showed no pathology. TOS and OSI were reported to be…

Electromagnetic field exposure (50 Hz) impairs response to noxious heat in American cockroach.

Research RF Safe Research Library Jan 1, 2018

This animal study examined whether 50 Hz electromagnetic field exposure (7 mT) affects heat-escape behavior and oxidative balance in American cockroaches. The authors report increased latency to escape from noxious heat after 24 h, 72 h, and 7 days of exposure. Biomarkers suggested oxidative stress, with elevated…

Selenium supplementation ameliorates electromagnetic field-induced oxidative stress in the HEK293 cells.

Research RF Safe Research Library Jan 1, 2018

This in vitro study examined whether selenium supplementation modifies oxidative stress and apoptosis markers in HEK293 cells exposed to 2.4 GHz EMF. The authors report that EMF exposure increased lipid peroxidation (MDA) and apoptosis-related markers while decreasing antioxidant enzyme activities and bcl-2 versus…

Expressions of some antioxidant genes in SH-SY5Y cells treated with β-lapachone, morphine and electromagnetic field.

Research RF Safe Research Library Jan 1, 2018

This in vitro study exposed SH-SY5Y cells to a 50 Hz, 0.50 mT electromagnetic field under intermittent or continuous conditions, alongside β-lapachone and/or morphine. The authors report condition-dependent changes in antioxidant gene expression, including decreased NQO1 and increased NQO2 under intermittent EMF…

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