Effects of pulse-modulated radiofrequency magnetic field (RF-EMF) exposure on apoptosis, autophagy, oxidative stress and electron chain transport function in human neuroblastoma and murine microglial cells.
This in vitro study exposed murine microglial (N9) and human neuroblastoma (SH-SY5Y) cells to ELF-modulated 935 MHz RF-EMF at 4 W/kg for 2 or 24 hours. The authors report no changes in apoptosis, cell viability, or AIF across conditions. They report increased ATG5 after 24 hours and a transient glutathione increase only in SH-SY5Y cells, suggesting cell-type- and duration-dependent changes in autophagy/oxidative stress markers under the tested conditions.
Key points
- Cells were sham-exposed or exposed to 935 MHz ELF-modulated RF-EMF at 4 W/kg for 2 or 24 hours.
- Apoptosis, number of living cells, and AIF were reported as unchanged in both cell types and exposure durations.
- ATG5 protein levels increased after 24 hours of exposure but not after 2 hours.
- LC3B-I/II and pERK were reported as not altered across cell types and exposure times.
- A transient glutathione increase was observed only in SH-SY5Y cells.
- Hydrogen peroxide and cytochrome c oxidase were reported as not changed under the tested conditions.
- The authors note that further studies are needed to investigate mechanisms for pulse-modulated RF-EMF effects.
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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