Electromagnetic Field Influence on the Bioavailability and Accumulation of Ketoprofen.
This in vitro/ex vivo study tested whether different magnetic-field configurations alter ketoprofen properties and its transdermal delivery in porcine skin using Franz diffusion cells. The authors report no change in ketoprofen molecular structure, but subtle changes in crystal structure and physicochemical properties after magnetic-field exposure. Pulsed and rotating magnetic fields were reported to improve permeation and dermal accumulation, while static negative polarity fields reduced transport/retention.
Key points
- Ketoprofen samples were exposed for 8 hours to oscillating, pulsed, static (positive/negative polarity), and rotating magnetic fields.
- Analyses included FTIR, XRD, thermal behavior, solubility, log P, and skin permeation/accumulation in porcine skin.
- The abstract reports ketoprofen molecular structure remained unchanged after exposure.
- Magnetic-field exposure was associated with subtle changes in crystal structure and physicochemical properties (including solubility and lipophilicity).
- Pulsed magnetic fields (PMF 10/10) and rotating magnetic fields (RMF 50 Hz) reportedly increased transdermal permeation and dermal accumulation.
- Static magnetic fields with negative polarity reportedly decreased drug transport and retention in skin tissue.
Referenced studies & papers
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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