Animal study on electromagnetic field biological potency.

Abstract

This recent basic research study used an animal model protocol to assess specific biomarkers of the effect of non-ionising, non-thermal radiation (2450 MHz microwave radiation at 5-15 mW/cm2) on bone marrow, peripheral blood, and bronchoalveolar free cell populations. Of 40 male Wistar rats taken in the study, 20 animals of the experimental group were irradiated for 2 hours a day, 5 days a week, and subsequently killed on days 1, 8, 16, and 30 of the experiment. The remaining 20 rats served as control. All animals were previously intratracheally instilled with biologically inert microspheres to see the influence of irradiation on lung retention kinetics. The cell response to chosen electromagnetic irradiation was followed quantitatively and qualitatively using the standard laboratory methods. The results of peripheral blood cell response suggested a decreasing tendency in total leukocyte count and in relative lymphocyte count in the treated group. A slight increase was also observed in granulocyte count and in the absolute count of peripheral blood erythrocytes over control animals.

AI evidence extraction

Main findings

In irradiated rats, peripheral blood results suggested a decreasing tendency in total leukocyte count and relative lymphocyte count. Slight increases were observed in granulocyte count and in absolute peripheral blood erythrocyte count compared with controls.

Outcomes measured

• Bone marrow biomarkers/cell populations
• Peripheral blood cell counts (total leukocytes, relative lymphocytes, granulocytes, erythrocytes)
• Bronchoalveolar free cell populations
• Lung retention kinetics of intratracheally instilled inert microspheres

Limitations

• No SAR reported (exposure described as 5–15 mW/cm2).
• Findings described as tendencies/slight changes; statistical significance not reported in the abstract.
• Only male rats studied; generalizability to other populations/species not addressed in the abstract.

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 2450,
        "sar_wkg": null,
        "duration": "2 hours/day, 5 days/week; animals killed on days 1, 8, 16, and 30"
    },
    "population": "Male Wistar rats",
    "sample_size": 40,
    "outcomes": [
        "Bone marrow biomarkers/cell populations",
        "Peripheral blood cell counts (total leukocytes, relative lymphocytes, granulocytes, erythrocytes)",
        "Bronchoalveolar free cell populations",
        "Lung retention kinetics of intratracheally instilled inert microspheres"
    ],
    "main_findings": "In irradiated rats, peripheral blood results suggested a decreasing tendency in total leukocyte count and relative lymphocyte count. Slight increases were observed in granulocyte count and in absolute peripheral blood erythrocyte count compared with controls.",
    "effect_direction": "mixed",
    "limitations": [
        "No SAR reported (exposure described as 5–15 mW/cm2).",
        "Findings described as tendencies/slight changes; statistical significance not reported in the abstract.",
        "Only male rats studied; generalizability to other populations/species not addressed in the abstract."
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "animal model",
        "Wistar rats",
        "microwave radiation",
        "2450 MHz",
        "non-ionising radiation",
        "non-thermal",
        "peripheral blood",
        "leukocytes",
        "lymphocytes",
        "granulocytes",
        "erythrocytes",
        "bone marrow",
        "bronchoalveolar cells",
        "lung retention kinetics",
        "microspheres"
    ],
    "suggested_hubs": []
}

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