The effect of microwave radiation on the stability and formation of gramicidin-A channels in lipid bilayer membranes.

PAPER pubmed Bioelectromagnetics 1991 In vitro study Effect: mixed Evidence: Low

Read original paper → DOI: 10.1002/bem.2250120103 PMID: 1707274 Evidence Lab

Abstract

The effects of microwaves on the single-channel kinetics of gramicidin-A channels in lipid bilayer membranes were examined. Attempts were made to separate thermal and athermal effects by accurate measurements of temperature at the site of the membrane and by relating the measured parameters to their previously characterized temperature dependence. It was found that microwave radiation does not affect single-channel conductance or channel life time to a degree that is significantly different from that expected of a purely thermal effect. On the other hand, the rate of channel formation is decreased during exposure, which is opposite to that expected of a purely thermal effect. The mechanism of this effect is discussed in terms of the dimerization process of channel formation.

AI evidence extraction

At a glance

Study type

In vitro study

Effect direction

mixed

Population

—

Sample size

—

Exposure

microwave

Evidence strength

Low

Confidence: 74% · Peer-reviewed: yes

Main findings

Microwave radiation did not affect single-channel conductance or channel lifetime beyond what was expected from purely thermal effects based on measured membrane-site temperature. However, the rate of channel formation decreased during exposure, opposite to what would be expected from a purely thermal effect.

Outcomes measured

single-channel conductance
channel lifetime
rate of channel formation
single-channel kinetics of gramicidin-A channels in lipid bilayer membranes

Limitations

Exposure parameters (e.g., frequency, SAR, duration) not reported in the provided abstract/metadata
In vitro lipid bilayer/gramicidin-A model; relevance to whole-organism health outcomes not addressed in the provided abstract

View raw extracted JSON

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": null,
    "sample_size": null,
    "outcomes": [
        "single-channel conductance",
        "channel lifetime",
        "rate of channel formation",
        "single-channel kinetics of gramicidin-A channels in lipid bilayer membranes"
    ],
    "main_findings": "Microwave radiation did not affect single-channel conductance or channel lifetime beyond what was expected from purely thermal effects based on measured membrane-site temperature. However, the rate of channel formation decreased during exposure, opposite to what would be expected from a purely thermal effect.",
    "effect_direction": "mixed",
    "limitations": [
        "Exposure parameters (e.g., frequency, SAR, duration) not reported in the provided abstract/metadata",
        "In vitro lipid bilayer/gramicidin-A model; relevance to whole-organism health outcomes not addressed in the provided abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "gramicidin-A",
        "lipid bilayer membranes",
        "single-channel kinetics",
        "thermal effects",
        "athermal effects",
        "channel formation",
        "dimerization"
    ],
    "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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