[K+,H+ and Cl- fluxes across erythrocyte membrane irradiated with radio frequency electromagnetic fields].

Abstract

The effect of 460 MHz microwave radiation on the ion-transporting properties of the isolated rat erythrocytes was studied with the use of K+, H+ and Cl(-)-selective electrodes. In comparison with the control cells kept at 0 degree C the most significant changes were observed in the K+ transport system. Particularly, microwave radiation (specific absorbed rate 280 W/kg) caused an increased loss of K+ during treatment and 2-fold decrease in the rate of K+ efflux from the irradiated erythrocytes, when the latter were incubated in the isoosmotic, unbuffered sucrose. The same changes were observed when the erythrocytes were conventionally heated up to 39 degrees C for 20 minutes. It is concluded that high levels of microwave radiation cause temperature-induced changes of the membrane structure resulting in alterations in potassium transport across the membrane.

AI evidence extraction

Main findings

Exposure to 460 MHz microwave radiation (SAR 280 W/kg) produced the most significant changes in the K+ transport system of isolated rat erythrocytes, including increased K+ loss during treatment and a 2-fold decrease in the rate of K+ efflux under specified incubation conditions. Similar changes occurred with conventional heating to 39°C for 20 minutes, and the authors conclude the microwave effects were temperature-induced membrane structural changes affecting potassium transport.

Outcomes measured

• K+ flux/transport
• H+ flux/transport
• Cl- flux/transport
• Erythrocyte membrane ion-transport properties

Limitations

• Sample size not reported in the abstract.
• Exposure duration for microwave irradiation not reported in the abstract.
• Study uses isolated rat erythrocytes (ex vivo), limiting direct inference to in vivo or human health outcomes.
• High SAR level (280 W/kg) may not reflect typical environmental exposures.
• Temperature control/measurement details during irradiation are not provided in the abstract.

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 460,
        "sar_wkg": 280,
        "duration": null
    },
    "population": "Isolated rat erythrocytes",
    "sample_size": null,
    "outcomes": [
        "K+ flux/transport",
        "H+ flux/transport",
        "Cl- flux/transport",
        "Erythrocyte membrane ion-transport properties"
    ],
    "main_findings": "Exposure to 460 MHz microwave radiation (SAR 280 W/kg) produced the most significant changes in the K+ transport system of isolated rat erythrocytes, including increased K+ loss during treatment and a 2-fold decrease in the rate of K+ efflux under specified incubation conditions. Similar changes occurred with conventional heating to 39°C for 20 minutes, and the authors conclude the microwave effects were temperature-induced membrane structural changes affecting potassium transport.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in the abstract.",
        "Exposure duration for microwave irradiation not reported in the abstract.",
        "Study uses isolated rat erythrocytes (ex vivo), limiting direct inference to in vivo or human health outcomes.",
        "High SAR level (280 W/kg) may not reflect typical environmental exposures.",
        "Temperature control/measurement details during irradiation are not provided in the abstract."
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "460 MHz",
        "microwave radiation",
        "SAR 280 W/kg",
        "rat erythrocytes",
        "potassium transport",
        "K+ efflux",
        "ion-selective electrodes",
        "thermal effects",
        "membrane structure"
    ],
    "suggested_hubs": []
}

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