Effect of microwave radiation on redissolving precipitated matter in fluorouracil injection.

PAPER pubmed American journal of hospital pharmacy 1980 Other Effect: no_effect Evidence: Low

Read original paper → PMID: 7386478 Evidence Lab

Abstract

The effect on the stability of fluorouracil injection of using microwave radiation to redissolve precipitated matter was studied. Fifteen ampuls each of Fluorouracil Injection, USP, containing precipitate were heated to 60 degrees C in a microwave oven and water bath, respectively. The contents of each heated ampul and of 15 control ampuls (unheated, no precipitate) were assayed by high-performance liquid chromatography, and the pH value of each sample was measured. Each test group fell within USP concentration requirements and showed no significant decrease in potency. Among the microwave-heated ampuls, a mean drop of 0.03 pH units was significant (p less than 0.05) but did not affect drug stability or solubility, since all samples remained within the USP pH range of 8.6-9.0. Precipitated matter in fluorouracil injection can be redissolved by heating with microwave radiation without significantly affecting the drug's stability.

AI evidence extraction

At a glance

Study type

Other

Effect direction

no_effect

Population

—

Sample size

Exposure

microwave microwave oven

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

Fifteen ampuls with precipitate heated to 60°C in a microwave oven and fifteen heated in a water bath, compared with 15 unheated controls, all met USP concentration requirements with no significant decrease in potency. Microwave-heated ampuls showed a statistically significant mean pH drop of 0.03 units (p<0.05) but remained within the USP pH range (8.6–9.0) and this did not affect stability or solubility; precipitate could be redissolved using microwave heating without significantly affecting stability.

Outcomes measured

fluorouracil injection potency (HPLC assay)
pH change
drug stability
drug solubility/redissolution of precipitate

Limitations

Microwave exposure parameters (e.g., frequency, power, duration) not reported in abstract
Small sample size (15 ampuls per group)
Study assesses pharmaceutical product stability rather than biological/health outcomes

View raw extracted JSON

{
    "study_type": "other",
    "exposure": {
        "band": "microwave",
        "source": "microwave oven",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": null,
    "sample_size": 45,
    "outcomes": [
        "fluorouracil injection potency (HPLC assay)",
        "pH change",
        "drug stability",
        "drug solubility/redissolution of precipitate"
    ],
    "main_findings": "Fifteen ampuls with precipitate heated to 60°C in a microwave oven and fifteen heated in a water bath, compared with 15 unheated controls, all met USP concentration requirements with no significant decrease in potency. Microwave-heated ampuls showed a statistically significant mean pH drop of 0.03 units (p<0.05) but remained within the USP pH range (8.6–9.0) and this did not affect stability or solubility; precipitate could be redissolved using microwave heating without significantly affecting stability.",
    "effect_direction": "no_effect",
    "limitations": [
        "Microwave exposure parameters (e.g., frequency, power, duration) not reported in abstract",
        "Small sample size (15 ampuls per group)",
        "Study assesses pharmaceutical product stability rather than biological/health outcomes"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "microwave oven",
        "fluorouracil injection",
        "precipitate",
        "redissolution",
        "stability",
        "potency",
        "pH",
        "HPLC",
        "USP"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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