In vitro effects of microwave radiation on rat liver mitochondria.

PAPER pubmed Bioelectromagnetics 1984 In vitro study Effect: mixed Evidence: Low

Read original paper → DOI: 10.1002/bem.2250050105 PMID: 6143563 Evidence Lab

Abstract

Liver mitochondria were exposed in vitro at 30 degrees C to microwave radiation (2.45 GHz) during the following states of respiration: resting, state 1; substrate dependent, state 2; ADP stimulated, state 3; and ADP depleted, state 4. At 10 or 100 mW/g, with succinate as substrate, no effect of exposure was observed on states 1-4 or the respiratory control index (state 3/state 4) of either tightly or loosely coupled mitochondria. When glutamate was used as substrate, no effects were observed at 10 mW/g. However, in the loosely coupled mitochondria the 100 mW/g exposure produced an increase in states 2 and 4 and a decrease in the respiratory control index. The results suggest that the function of loosely coupled mitochondria can be affected at high power levels of microwave radiation.

AI evidence extraction

At a glance

Study type

In vitro study

Effect direction

mixed

Population

rat liver mitochondria

Sample size

—

Exposure

microwave · 2450 MHz

Evidence strength

Low

Confidence: 60% · Peer-reviewed: yes

Main findings

Exposure to 2.45 GHz microwave radiation at 10 or 100 mW/g had no effect on mitochondrial respiration states or respiratory control index with succinate substrate. With glutamate substrate, 100 mW/g exposure increased states 2 and 4 and decreased respiratory control index in loosely coupled mitochondria.

Outcomes measured

mitochondrial respiration states 1-4
respiratory control index

Limitations

in vitro study only
no information on exposure duration
limited to rat liver mitochondria
only two power levels tested

View raw extracted JSON

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 2450,
        "sar_wkg": null,
        "duration": null
    },
    "population": "rat liver mitochondria",
    "sample_size": null,
    "outcomes": [
        "mitochondrial respiration states 1-4",
        "respiratory control index"
    ],
    "main_findings": "Exposure to 2.45 GHz microwave radiation at 10 or 100 mW/g had no effect on mitochondrial respiration states or respiratory control index with succinate substrate. With glutamate substrate, 100 mW/g exposure increased states 2 and 4 and decreased respiratory control index in loosely coupled mitochondria.",
    "effect_direction": "mixed",
    "limitations": [
        "in vitro study only",
        "no information on exposure duration",
        "limited to rat liver mitochondria",
        "only two power levels tested"
    ],
    "evidence_strength": "low",
    "confidence": 0.59999999999999997779553950749686919152736663818359375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "mitochondria",
        "in vitro",
        "respiration",
        "rat liver"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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