Reduced mitogenic stimulation of human lymphocytes by extremely low frequency electromagnetic fields.

PAPER pubmed FEBS letters 1983 In vitro study Effect: harm Evidence: Very low

Read original paper → DOI: 10.1016/0014-5793(83)81069-2 PMID: 6617888 Evidence Lab

Abstract

Blastogenesis of human peripheral blood lymphocytes stimulated in vitro by non-specific mitogens (PHA, ConA, PWM) upon exposure to extremely low frequency EMF has been studied. Different frequencies of square waveforms have been used. PHA-stimulation resulted in strong inhibitions as measured by [3H]thymidine incorporation. A frequency window (3-50 Hz) within which ConA-induced blastogenesis was significantly inhibited has been individuated. The mitogenic effect of PWM was significantly affected only at 3 Hz.

AI evidence extraction

At a glance

Study type

In vitro study

Effect direction

harm

Population

Human peripheral blood lymphocytes (in vitro)

Sample size

—

Exposure

ELF

Evidence strength

Very low

Confidence: 74% · Peer-reviewed: yes

Main findings

In vitro exposure to extremely low frequency EMF (square waveforms) was associated with reduced mitogen-stimulated blastogenesis of human peripheral blood lymphocytes. PHA stimulation showed strong inhibition by [3H]thymidine incorporation; ConA-induced blastogenesis was significantly inhibited within a 3–50 Hz frequency window; PWM effects were significantly affected only at 3 Hz.

Outcomes measured

Lymphocyte blastogenesis/mitogenic stimulation (PHA, ConA, PWM)
[3H]thymidine incorporation

Limitations

No sample size reported in abstract
Exposure intensity/field strength not reported in abstract
Exposure duration not reported in abstract
In vitro study; generalizability to in vivo health outcomes is unclear

View raw extracted JSON

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "ELF",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Human peripheral blood lymphocytes (in vitro)",
    "sample_size": null,
    "outcomes": [
        "Lymphocyte blastogenesis/mitogenic stimulation (PHA, ConA, PWM)",
        "[3H]thymidine incorporation"
    ],
    "main_findings": "In vitro exposure to extremely low frequency EMF (square waveforms) was associated with reduced mitogen-stimulated blastogenesis of human peripheral blood lymphocytes. PHA stimulation showed strong inhibition by [3H]thymidine incorporation; ConA-induced blastogenesis was significantly inhibited within a 3–50 Hz frequency window; PWM effects were significantly affected only at 3 Hz.",
    "effect_direction": "harm",
    "limitations": [
        "No sample size reported in abstract",
        "Exposure intensity/field strength not reported in abstract",
        "Exposure duration not reported in abstract",
        "In vitro study; generalizability to in vivo health outcomes is unclear"
    ],
    "evidence_strength": "very_low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "extremely low frequency",
        "ELF",
        "electromagnetic fields",
        "square waveform",
        "frequency window",
        "lymphocytes",
        "blastogenesis",
        "mitogens",
        "PHA",
        "ConA",
        "PWM",
        "thymidine incorporation"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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