The effect of electromagnetic field exposure on the formation of DNA single strand breaks in human cells.

PAPER pubmed Cellular and molecular biology (Noisy-le-Grand, France) 1994 In vitro study Effect: no_effect Evidence: Low

Read original paper → PMID: 8061573 Evidence Lab

Abstract

Electromagnetic fields (EMF) have been reported to be associated with human cancers in a number of epidemiological studies. Agents that are associated with cancer affect DNA in an adverse manner. This is a report of a DNA damage study in human cells exposed to EMFs. Single strand breaks in DNA are proposed to be necessary events in both mutagenesis and carcinogenesis. The single cell gel assay is a sensitive and accurate technique that was used in this study for single strand break detection. The EMF exposure system used here appeared to have no direct effect on DNA damage induction in a series of experiments. Moreover, EMF did not have a significant effect in potentiating DNA damage in cells treated with oxidative stresses.

AI evidence extraction

At a glance

Study type

In vitro study

Effect direction

no_effect

Population

Human cells (in vitro)

Sample size

—

Exposure

unknown other

Evidence strength

Low

Confidence: 74% · Peer-reviewed: yes

Main findings

Using the single cell gel assay, the EMF exposure system used in this study appeared to have no direct effect on DNA single strand break/DNA damage induction across a series of experiments. EMF also did not significantly potentiate DNA damage in cells treated with oxidative stresses.

Outcomes measured

DNA single strand breaks
DNA damage induction
Potentiation of DNA damage under oxidative stress

Limitations

EMF exposure characteristics (e.g., frequency, intensity/SAR, duration) are not specified in the abstract.
Cell type(s) and experimental details are not provided in the abstract.
Sample size and statistical details are not reported in the abstract.

View raw extracted JSON

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "unknown",
        "source": "other",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Human cells (in vitro)",
    "sample_size": null,
    "outcomes": [
        "DNA single strand breaks",
        "DNA damage induction",
        "Potentiation of DNA damage under oxidative stress"
    ],
    "main_findings": "Using the single cell gel assay, the EMF exposure system used in this study appeared to have no direct effect on DNA single strand break/DNA damage induction across a series of experiments. EMF also did not significantly potentiate DNA damage in cells treated with oxidative stresses.",
    "effect_direction": "no_effect",
    "limitations": [
        "EMF exposure characteristics (e.g., frequency, intensity/SAR, duration) are not specified in the abstract.",
        "Cell type(s) and experimental details are not provided in the abstract.",
        "Sample size and statistical details are not reported in the abstract."
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "electromagnetic fields",
        "EMF",
        "DNA damage",
        "single strand breaks",
        "single cell gel assay",
        "comet assay",
        "oxidative stress",
        "human cells",
        "mutagenesis",
        "carcinogenesis"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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