Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields.

Abstract

Several studies indicating a decline of DNA repair efficiency with age raise the question, if senescence per se leads to a higher susceptibility to DNA damage upon environmental exposures. Cultured fibroblasts of six healthy donors of different age exposed to intermittent ELF-EMF (50 Hz sinus, 1 mT) for 1-24 h exhibited different basal DNA strand break levels correlating with age. The cells revealed a maximum response at 15-19 h of exposure. This response was clearly more pronounced in cells from older donors, which could point to an age-related decrease of DNA repair efficiency of ELF-EMF induced DNA strand breaks.

AI evidence extraction

Main findings

Cultured fibroblasts exposed to intermittent 50 Hz (1 mT) ELF-EMF for 1–24 h showed basal DNA strand break levels that correlated with donor age. A maximum response occurred at 15–19 h and was more pronounced in cells from older donors.

Outcomes measured

• DNA strand breaks
• Basal DNA strand break levels
• Age-related differences in response to ELF-EMF exposure

Limitations

• In vitro study (cultured fibroblasts), not an in vivo or clinical outcome
• Small donor sample (six donors)
• Mechanism (DNA repair efficiency) is suggested but not directly demonstrated in the abstract

Suggested hubs

• who-icnirp (0.2)
  Study concerns ELF-EMF exposure and DNA damage, relevant to EMF health risk assessment discussions.

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "ELF",
        "source": null,
        "frequency_mhz": 0.05000000000000000277555756156289135105907917022705078125,
        "sar_wkg": null,
        "duration": "1–24 h (maximum response at 15–19 h); intermittent exposure"
    },
    "population": "Cultured fibroblasts from six healthy human donors of different age",
    "sample_size": 6,
    "outcomes": [
        "DNA strand breaks",
        "Basal DNA strand break levels",
        "Age-related differences in response to ELF-EMF exposure"
    ],
    "main_findings": "Cultured fibroblasts exposed to intermittent 50 Hz (1 mT) ELF-EMF for 1–24 h showed basal DNA strand break levels that correlated with donor age. A maximum response occurred at 15–19 h and was more pronounced in cells from older donors.",
    "effect_direction": "harm",
    "limitations": [
        "In vitro study (cultured fibroblasts), not an in vivo or clinical outcome",
        "Small donor sample (six donors)",
        "Mechanism (DNA repair efficiency) is suggested but not directly demonstrated in the abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "ELF-EMF",
        "50 Hz",
        "1 mT",
        "intermittent exposure",
        "fibroblasts",
        "DNA strand breaks",
        "age-related effects",
        "DNA repair"
    ],
    "suggested_hubs": [
        {
            "slug": "who-icnirp",
            "weight": 0.200000000000000011102230246251565404236316680908203125,
            "reason": "Study concerns ELF-EMF exposure and DNA damage, relevant to EMF health risk assessment discussions."
        }
    ]
}

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