900-MHz microwave radiation enhances gamma-ray adverse effects on SHG44 cells.

PAPER pubmed Journal of toxicology and environmental health. Part A 2009 In vitro study Effect: harm Evidence: Low

Read original paper → DOI: 10.1080/15287390902841466 PMID: 19492235 Evidence Lab

Abstract

Mobile phones are widely used globally. However, the biological effects due to exposure to electromagnetic fields (EMF) produced by mobile phones are largely unknown. Environmental and occupational exposure of humans to gamma-rays is a biologically relevant phenomenon. Consequently studies were undertaken to examine the interactions between gamma-rays and EMF on human health. In this study, exposure to 900-MHz EMF expanded gamma-ray damage to SHG44 cells. Preexposure EMF enhanced the decrease in cell proliferation induced by gamma-ray irradiation and the rate of apoptosis. The combination of EMF and gamma-ray exposure resulted in a synergistic effect by triggering stress response, which increased reactive oxygen species, but the expression of hsp70 at both mRNA and protein levels remained unaltered. Data indicate that the adverse effects of gamma-rays on cellular functions are strengthened by EMF.

AI evidence extraction

At a glance

Study type

In vitro study

Effect direction

harm

Population

SHG44 cells (human cell line)

Sample size

—

Exposure

RF mobile phone · 900 MHz

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

In SHG44 cells, exposure to 900-MHz EMF increased gamma-ray-associated damage. EMF preexposure enhanced the gamma-ray-induced decrease in cell proliferation and increased apoptosis; combined EMF and gamma-ray exposure produced a synergistic stress response with increased ROS, while hsp70 expression at mRNA and protein levels was unchanged.

Outcomes measured

gamma-ray-induced cell damage
cell proliferation
apoptosis
stress response
reactive oxygen species (ROS)
hsp70 expression (mRNA and protein)

Limitations

In vitro cell model; findings may not translate to humans
Exposure parameters beyond frequency (e.g., SAR, duration) not reported in the abstract
Sample size not reported in the abstract

View raw extracted JSON

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "RF",
        "source": "mobile phone",
        "frequency_mhz": 900,
        "sar_wkg": null,
        "duration": null
    },
    "population": "SHG44 cells (human cell line)",
    "sample_size": null,
    "outcomes": [
        "gamma-ray-induced cell damage",
        "cell proliferation",
        "apoptosis",
        "stress response",
        "reactive oxygen species (ROS)",
        "hsp70 expression (mRNA and protein)"
    ],
    "main_findings": "In SHG44 cells, exposure to 900-MHz EMF increased gamma-ray-associated damage. EMF preexposure enhanced the gamma-ray-induced decrease in cell proliferation and increased apoptosis; combined EMF and gamma-ray exposure produced a synergistic stress response with increased ROS, while hsp70 expression at mRNA and protein levels was unchanged.",
    "effect_direction": "harm",
    "limitations": [
        "In vitro cell model; findings may not translate to humans",
        "Exposure parameters beyond frequency (e.g., SAR, duration) not reported in the abstract",
        "Sample size not reported in the abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "900 MHz",
        "RF EMF",
        "mobile phone",
        "gamma rays",
        "SHG44 cells",
        "apoptosis",
        "cell proliferation",
        "reactive oxygen species",
        "hsp70",
        "synergistic effect",
        "stress response"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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