Effects of extremely low-frequency electromagnetic field on fertility and heights of epithelial cells in pre-implantation stage endometrium and fallopian tube in mice.

PAPER pubmed Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 2010 Randomized trial Effect: harm Evidence: Moderate

Read original paper → DOI: 10.3736/jcim20100111 PMID: 20082760 Evidence Lab

Abstract

OBJECTIVE: To investigate the effects of extremely low-frequency electromagnetic field (ELF-EMF) on fertility and heights of epithelial cells in pre-implantation stage endometrium and fallopian tube in mice. METHODS: Eighty female NMRI mice were randomly divided into 2 groups: control group was not exposed to EMF and experimental group was exposed to 4-hour EMF per day, 6 days a week for 2 weeks to 50 Hz, 0.5 mT EMF. Female mice in two groups were superovulated and mated with male mice over night. At the time of implantation, the blastocysts were obtained from the presumed pregnant mice with vaginal plug by flushing the uterus horns. The samples of uterus horns and fallopian tubes in two groups were taken and were processed for light microscopic studies. RESULTS: The analysis of mean number of the flushed blastocysts in the EMF group showed significant decrease as compared with the control group (P<0.03). Light microscopic study showed that the height of fallopian tube epithelial cells was significantly increased in the EMF group as compared with the control group (P<0.001). However the height of endometrial epithelial cells in the EMF group showed insignificant increase as compared with the control group. CONCLUSION: The results indicate that ELF-EMF has detrimental effect on female reproductive system in mice by decreasing the number of flushed blastocysts and increasing the height of fallopian tube epithelial cells.

AI evidence extraction

At a glance

Study type

Randomized trial

Effect direction

harm

Population

female NMRI mice

Sample size

Exposure

ELF · 0.05 MHz · 4 hours per day, 6 days a week for 2 weeks

Evidence strength

Moderate

Confidence: 70% · Peer-reviewed: yes

Main findings

Exposure to 50 Hz, 0.5 mT ELF-EMF for 4 hours daily over 2 weeks significantly decreased the number of flushed blastocysts and significantly increased the height of fallopian tube epithelial cells in mice. The height of endometrial epithelial cells showed an insignificant increase.

Outcomes measured

number of flushed blastocysts
height of fallopian tube epithelial cells
height of endometrial epithelial cells

Limitations

Study conducted in mice, limiting direct human applicability
Exposure parameters specific and may not represent typical human exposures
No long-term fertility outcomes assessed

Suggested hubs

occupational-exposure (0.6)
ELF-EMF exposure relevant to occupational or environmental settings.

View raw extracted JSON

{
    "study_type": "randomized_trial",
    "exposure": {
        "band": "ELF",
        "source": null,
        "frequency_mhz": 0.05000000000000000277555756156289135105907917022705078125,
        "sar_wkg": null,
        "duration": "4 hours per day, 6 days a week for 2 weeks"
    },
    "population": "female NMRI mice",
    "sample_size": 80,
    "outcomes": [
        "number of flushed blastocysts",
        "height of fallopian tube epithelial cells",
        "height of endometrial epithelial cells"
    ],
    "main_findings": "Exposure to 50 Hz, 0.5 mT ELF-EMF for 4 hours daily over 2 weeks significantly decreased the number of flushed blastocysts and significantly increased the height of fallopian tube epithelial cells in mice. The height of endometrial epithelial cells showed an insignificant increase.",
    "effect_direction": "harm",
    "limitations": [
        "Study conducted in mice, limiting direct human applicability",
        "Exposure parameters specific and may not represent typical human exposures",
        "No long-term fertility outcomes assessed"
    ],
    "evidence_strength": "moderate",
    "confidence": 0.6999999999999999555910790149937383830547332763671875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "ELF-EMF",
        "fertility",
        "blastocysts",
        "fallopian tube",
        "epithelial cells",
        "mice"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.59999999999999997779553950749686919152736663818359375,
            "reason": "ELF-EMF exposure relevant to occupational or environmental settings."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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