Effects of 50Hz Homogeneous Ferromagnetic Field on the Concentrations of Intracellular Calcium-ion of SNU Cells and Lymphma Cells In Vitro.

Abstract

The study was designed to observe the effects of 50 Hz homogeneous ferromagnetic field (0.097T) exposure on change of intracellular Calcium-ion concentration of human low differentiation gastric adenocarcinoma cell line - SNU and lymphocytes in vitro. SNU cells and human peripheral blood lymphocytes in vitro were exposured to 50 Hz homogeneous ferromagnetic field at different time periods. Cells were harvested after magnetic field exposure. The concentration of intracellular Calcium-ion of cells in control and different experimental groups were measured with confocal microscope. The concentration of intracellular Calcium-ion of SNU cells and human peripheral blood lymphocytes were all increased after magnetic field exposure. 50Hz homogeneous ferromagnetic field exposure could induce increases of the concentration of intracellular Calcium-ion of SNU cells and human peripheral blood lymphocytes in vitro.

AI evidence extraction

Main findings

SNU cells and human peripheral blood lymphocytes showed increased intracellular calcium-ion concentration after exposure to a 50 Hz homogeneous ferromagnetic field (0.097 T) across different exposure time periods.

Outcomes measured

• Intracellular calcium-ion concentration (measured by confocal microscope)

Limitations

• In vitro study; findings may not translate to in vivo or human health outcomes
• Exposure durations/time periods not specified in the abstract
• Sample size and replication not reported in the abstract
• Only one biological endpoint (intracellular calcium) reported

Suggested hubs

• elf-magnetic-fields (0.9)
  Study examines biological effects of 50 Hz magnetic field exposure.

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    "study_type": "in_vitro",
    "exposure": {
        "band": "ELF",
        "source": "other",
        "frequency_mhz": 0.05000000000000000277555756156289135105907917022705078125,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Human low differentiation gastric adenocarcinoma cell line (SNU) and human peripheral blood lymphocytes (in vitro)",
    "sample_size": null,
    "outcomes": [
        "Intracellular calcium-ion concentration (measured by confocal microscope)"
    ],
    "main_findings": "SNU cells and human peripheral blood lymphocytes showed increased intracellular calcium-ion concentration after exposure to a 50 Hz homogeneous ferromagnetic field (0.097 T) across different exposure time periods.",
    "effect_direction": "harm",
    "limitations": [
        "In vitro study; findings may not translate to in vivo or human health outcomes",
        "Exposure durations/time periods not specified in the abstract",
        "Sample size and replication not reported in the abstract",
        "Only one biological endpoint (intracellular calcium) reported"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "50 Hz",
        "ELF magnetic field",
        "ferromagnetic field",
        "0.097 T",
        "SNU cells",
        "gastric adenocarcinoma cell line",
        "peripheral blood lymphocytes",
        "intracellular calcium",
        "confocal microscope",
        "in vitro"
    ],
    "suggested_hubs": [
        {
            "slug": "elf-magnetic-fields",
            "weight": 0.90000000000000002220446049250313080847263336181640625,
            "reason": "Study examines biological effects of 50 Hz magnetic field exposure."
        }
    ]
}

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