Influence of electromagnetic field (1800 MHz) on lipid peroxidation in brain, blood, liver and kidney in rats

PAPER manual 2015 Animal study Effect: harm Evidence: Low

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Abstract

Int J Occup Med Environ Health . 2015;28(4):751-9. doi: 10.13075/ijomeh.1896.00255. Influence of electromagnetic field (1800 MHz) on lipid peroxidation in brain, blood, liver and kidney in rats Paweł Bodera 1, Wanda Stankiewicz 2, Bożena Antkowiak 3, Małgorzata Paluch 3, Jarosław Kieliszek 2, Jaromir Sobiech 2, Marcin Niemcewicz 4 Affiliations Expand PMID: 26216313 DOI: 10.13075/ijomeh.1896.00255 Free article Abstract Objectives: The aim of this study is the evaluation of the influence of repeated (5 times for 15 min) exposure to electromagnetic field (EMF) of 1800 MHz frequency on tissue lipid peroxidation (LPO) both in normal and inflammatory state, combined with analgesic treatment. Material and methods: The concentration of malondialdehyde (MDA) as the end-product of the lipid peroxidation (LPO) was estimated in blood, liver, kidneys, and brain of Wistar rats, both healthy and those with complete Freund's adjuvant (CFA)-induced persistent paw inflammation. Results: The slightly elevated levels of the MDA in blood, kidney, and brain were observed among healthy rats in electromagnetic field (EMF)-exposed groups, treated with tramadol (TRAM/EMF and exposed to the EMF). The malondialdehyde remained at the same level in the liver in all investigated groups: the control group (CON), the exposed group (EMF), treated with tramadol (TRAM) as well as exposed to and treated with tramadol (TRAM/EMF). In the group of animals treated with the complete Freund's adjuvant (CFA) we also observed slightly increased values of the MDA in the case of the control group (CON) and the exposed groups (EMF and TRAM/EMF). The MDA values concerning kidneys remained at the same levels in the control, exposed, and not-exposed group treated with tramadol. Results for healthy rats and animals with inflammation did not differ significantly. Conclusions: The electromagnetic field exposure (EMF), applied in the repeated manner together with opioid drug tramadol (TRAM), slightly enhanced lipid peroxidation level in brain, blood, and kidneys. Keywords: analgesics; electromagnetic field; lipid peroxidation; malondialdehyde; rats; tramadol.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Wistar rats, healthy and with CFA-induced persistent paw inflammation

Sample size

—

Exposure

· 1800 MHz · 5 times for 15 min repeated exposure

Evidence strength

Low

Confidence: 50% · Peer-reviewed: yes

Main findings

Repeated exposure to 1800 MHz EMF combined with tramadol slightly increased lipid peroxidation levels in brain, blood, and kidneys of healthy rats; no significant differences were observed between healthy and inflamed rats.

Outcomes measured

lipid peroxidation measured by malondialdehyde (MDA) concentration in blood, liver, kidneys, and brain

Limitations

sample size not specified
only one frequency and exposure duration tested
study limited to animal model

Suggested hubs

occupational-exposure (0.7)
study of 1800 MHz EMF exposure relevant to occupational or environmental EMF exposure

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": null,
        "source": null,
        "frequency_mhz": 1800,
        "sar_wkg": null,
        "duration": "5 times for 15 min repeated exposure"
    },
    "population": "Wistar rats, healthy and with CFA-induced persistent paw inflammation",
    "sample_size": null,
    "outcomes": [
        "lipid peroxidation measured by malondialdehyde (MDA) concentration in blood, liver, kidneys, and brain"
    ],
    "main_findings": "Repeated exposure to 1800 MHz EMF combined with tramadol slightly increased lipid peroxidation levels in brain, blood, and kidneys of healthy rats; no significant differences were observed between healthy and inflamed rats.",
    "effect_direction": "harm",
    "limitations": [
        "sample size not specified",
        "only one frequency and exposure duration tested",
        "study limited to animal model"
    ],
    "evidence_strength": "low",
    "confidence": 0.5,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "electromagnetic field",
        "1800 MHz",
        "lipid peroxidation",
        "malondialdehyde",
        "rats",
        "tramadol",
        "opioid analgesic"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.6999999999999999555910790149937383830547332763671875,
            "reason": "study of 1800 MHz EMF exposure relevant to occupational or environmental EMF exposure"
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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