Human achromatic flickers and phosphenes thresholds under extremely low frequency electric stimulations

PAPER manual Sci Rep 2025 Other Effect: mixed Evidence: Low

Read original paper → DOI: 10.1038/s41598-025-06271-8 Evidence Lab

Abstract

Category: Neuroscience Tags: electromagnetic fields, ELF, health risk, phosphenes, visual perception, electric stimulation, exposure guidelines DOI: 10.1038/s41598-025-06271-8 URL: nature.com Overview Human exposure to extremely low-frequency (< 300 Hz) electric and magnetic fields can cause a distinct stroboscopic visual sensation known as electro/magneto phosphenes. The induction of these visual effects represents one of the most comprehensively documented outcomes of in-situ electric field interaction with human tissues. Notably, international safety guidelines use phosphenes as a key biological marker to set exposure limits for extremely low-frequency (ELF) electric and magnetic fields. Methods - Objective: Estimate the location (locus) and threshold for perceiving phosphenes during electric current stimulation at four frequencies: 20, 50, 60, and 100 Hz. - Participants: 20 volunteers underwent non-invasive transcranial alternating current stimulation, ranging from 0 to 2 mA at the specified frequencies. - Analysis: Logistic regressions were used on perceptual data to calculate probabilities of phosphene perception, and dosimetry analyses quantified in-situ electric field levels in the retina. Findings - The intensity of the stimulation current had a significant impact on phosphene perception across all frequencies. - The lowest threshold for phosphene perception occurred at 20 Hz. - No perceivable phosphenes were reported at 100 Hz. - The data reinforces the retinal origin of phosphenes and highlights the sensitivity of the human visual system to ELF electric stimulation. Conclusion These results are vital for decoding the underlying mechanisms of phosphene induction due to ELF field exposure. Furthermore, the identified perception thresholds and trends offer essential insights to inform revisions of international safety standards for human exposure to electromagnetic fields. Importantly, this study underscores a clear connection between ELF field exposure and specific neurological responses, signifying the necessity for cautious exposure limits to protect public health.

AI evidence extraction

At a glance

Study type

Other

Effect direction

mixed

Population

20 volunteers

Sample size

Exposure

ELF electric stimulation

Evidence strength

Low

Confidence: 74% · Peer-reviewed: yes

Main findings

In 20 volunteers receiving non-invasive transcranial alternating current stimulation (0–2 mA) at 20, 50, 60, and 100 Hz, stimulation intensity significantly affected phosphene perception across frequencies. The lowest perception threshold occurred at 20 Hz, and no perceivable phosphenes were reported at 100 Hz; dosimetry analyses supported a retinal origin of the phosphenes.

Outcomes measured

phosphene perception threshold
phosphene perception probability
locus/location of phosphene perception (retinal origin)

Suggested hubs

who-icnirp (0.62)
Abstract explicitly links phosphene thresholds to international safety guidelines for ELF electric and magnetic fields.

View raw extracted JSON

{
    "study_type": "other",
    "exposure": {
        "band": "ELF",
        "source": "electric stimulation",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "20 volunteers",
    "sample_size": 20,
    "outcomes": [
        "phosphene perception threshold",
        "phosphene perception probability",
        "locus/location of phosphene perception (retinal origin)"
    ],
    "main_findings": "In 20 volunteers receiving non-invasive transcranial alternating current stimulation (0–2 mA) at 20, 50, 60, and 100 Hz, stimulation intensity significantly affected phosphene perception across frequencies. The lowest perception threshold occurred at 20 Hz, and no perceivable phosphenes were reported at 100 Hz; dosimetry analyses supported a retinal origin of the phosphenes.",
    "effect_direction": "mixed",
    "limitations": [],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "extremely low frequency",
        "ELF",
        "electric stimulation",
        "transcranial alternating current stimulation",
        "tACS",
        "phosphenes",
        "magnetophosphenes",
        "electrophosphenes",
        "visual perception",
        "retina",
        "exposure guidelines",
        "safety standards"
    ],
    "suggested_hubs": [
        {
            "slug": "who-icnirp",
            "weight": 0.61999999999999999555910790149937383830547332763671875,
            "reason": "Abstract explicitly links phosphene thresholds to international safety guidelines for ELF electric and magnetic fields."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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