Effects of Light-Induced Electromagnetic Fields on Human Cancer Cells .

Abstract

PURPOSE: This study investigates two electromagnetic field (EMF) modalities on cancer cells: near-infrared pulsating light (NIR) and hyperpolarized light (HPL). METHODS: PC3, MCF7, and HeLa were exposed to Bioptron (HPL, 40 mW/cm) and VieLight NeuroPro (NIR, 4.59 mW/cm, 810 nm, 10 Hz) for 10-60 min, with intermittent breaks. Viability, cytoskeletal and mitochondrial morphology, ATP, and lactate levels were assessed. RESULTS: NIR primarily enhanced mitochondrial ATP production, while HPL induced early morphological changes. Both modalities showed exposure dependency on viability. CONCLUSION: The analysis reveals distinct cellular responses to NIR and HPL, underscoring the importance of optimized protocols for effective EMF therapies.

AI evidence extraction

Main findings

In PC3, MCF7, and HeLa cells, NIR exposure primarily enhanced mitochondrial ATP production, while HPL induced early morphological changes. Both modalities showed exposure-dependent effects on viability.

Outcomes measured

• cell viability
• cytoskeletal morphology
• mitochondrial morphology
• ATP levels
• lactate levels

Suggested hubs

• other (0.35)
  In vitro study of light-based EMF modalities (NIR/HPL) on cancer cell lines; not clearly tied to RF/ELF consumer or occupational sources.

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    "study_type": "in_vitro",
    "exposure": {
        "band": null,
        "source": "near-infrared pulsating light (NIR) and hyperpolarized light (HPL) devices",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "10–60 min with intermittent breaks"
    },
    "population": null,
    "sample_size": null,
    "outcomes": [
        "cell viability",
        "cytoskeletal morphology",
        "mitochondrial morphology",
        "ATP levels",
        "lactate levels"
    ],
    "main_findings": "In PC3, MCF7, and HeLa cells, NIR exposure primarily enhanced mitochondrial ATP production, while HPL induced early morphological changes. Both modalities showed exposure-dependent effects on viability.",
    "effect_direction": "mixed",
    "limitations": [],
    "evidence_strength": "insufficient",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "near-infrared",
        "pulsating light",
        "hyperpolarized light",
        "Bioptron",
        "VieLight NeuroPro",
        "PC3",
        "MCF7",
        "HeLa",
        "ATP",
        "mitochondria",
        "cell viability"
    ],
    "suggested_hubs": [
        {
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            "weight": 0.34999999999999997779553950749686919152736663818359375,
            "reason": "In vitro study of light-based EMF modalities (NIR/HPL) on cancer cell lines; not clearly tied to RF/ELF consumer or occupational sources."
        }
    ]
}

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