Increasing levels of saliva alpha amylase in electrohypersensitive (EHS) patients

PAPER manual 2017 Case-control study Effect: mixed Evidence: Low

Read original paper → DOI: 10.1080/09553002.2017.1325971 Evidence Lab

Abstract

- Increasing levels of saliva alpha amylase in electrohypersensitive (EHS) patients Andrianome S, Hugueville L, de Seze R, Selmaoui B. Increasing levels of saliva alpha amylase in electrohypersensitive (EHS) patients.Int J Radiat Biol. 2017 May 3:1-24. doi: 10.1080/09553002.2017.1325971. . Abstract THE PURPOSE: The objective of this study was to assess the level of various salivary and urinary markers of patients with EHS and to compare them with those of the healthy control group. MATERIALS AND METHODS: We analyzed samples from 30 EHS individuals and a matched control group of 25 individuals (non EHS) aged between 22 and 66. We quantified cortisol both in saliva and urine, alpha amylase (sAA), immunoglobulin A and C Reactive Protein levels in saliva and neopterin in urine (uNeopterin). RESULTS: sAA was found to be significantly higher (p < 0.005) in the EHS group. uNeopterin and sAA analysis showed a significant difference based on the duration of EHS. CONCLUSION: Higher level of sAA in EHS participants may suggest that the sympathetic adrenal medullar system is activated. However, most of the analyzed markers of the immune system, sympathetic activity and circadian rhythm did not vary significantly in EHS group. There is a trend to the higher levels of some variables in subgroups according to the EHS duration.

AI evidence extraction

At a glance

Study type

Case-control study

Effect direction

mixed

Population

30 EHS individuals and 25 matched healthy controls aged 22-66

Sample size

Exposure

electrohypersensitivity (EHS)

Evidence strength

Low

Confidence: 40% · Peer-reviewed: yes

Main findings

Saliva alpha amylase (sAA) was significantly higher in the EHS group compared to controls. Urinary neopterin and sAA levels showed significant differences based on EHS duration. Other markers of immune system, sympathetic activity, and circadian rhythm did not vary significantly.

Outcomes measured

saliva alpha amylase (sAA)
cortisol in saliva and urine
immunoglobulin A in saliva
C Reactive Protein in saliva
urinary neopterin (uNeopterin)

Limitations

Small sample size
EHS diagnosis and exposure not objectively measured
Cross-sectional design limits causal inference

View raw extracted JSON

{
    "study_type": "case_control",
    "exposure": {
        "band": null,
        "source": "electrohypersensitivity (EHS)",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "30 EHS individuals and 25 matched healthy controls aged 22-66",
    "sample_size": 55,
    "outcomes": [
        "saliva alpha amylase (sAA)",
        "cortisol in saliva and urine",
        "immunoglobulin A in saliva",
        "C Reactive Protein in saliva",
        "urinary neopterin (uNeopterin)"
    ],
    "main_findings": "Saliva alpha amylase (sAA) was significantly higher in the EHS group compared to controls. Urinary neopterin and sAA levels showed significant differences based on EHS duration. Other markers of immune system, sympathetic activity, and circadian rhythm did not vary significantly.",
    "effect_direction": "mixed",
    "limitations": [
        "Small sample size",
        "EHS diagnosis and exposure not objectively measured",
        "Cross-sectional design limits causal inference"
    ],
    "evidence_strength": "low",
    "confidence": 0.40000000000000002220446049250313080847263336181640625,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "electrohypersensitivity",
        "saliva alpha amylase",
        "sympathetic adrenal medullar system",
        "immune markers",
        "biomarkers"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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