Neuroprotective Efficacy of Luteolin on a 900-MHz Electromagnetic Field-Induced Cerebellar Alteration in Adult Male Rat

PAPER manual Brain research 2020 Animal study Effect: mixed Evidence: Low

Read original paper → DOI: 10.1016/j.brainres.2020.146919 PMID: 32485174 Evidence Lab

Abstract

Neuroprotective Efficacy of Luteolin on a 900-MHz Electromagnetic Field-Induced Cerebellar Alteration in Adult Male Rat Ahmad Yahyazadeh, Berrin Zuhal Altunkaynak. Neuroprotective Efficacy of Luteolin on a 900-MHz Electromagnetic Field-Induced Cerebellar Alteration in Adult Male Rat. Brain Res. 2020 May 30;146919. doi: 10.1016/j.brainres.2020.146919. Abstract The adverse health consequences of exposure to electromagnetic field emitted from cell phone has recently raised public concerns worldwide. Also, the Global System for Mobile Communications (GSM) standard that operates in 900 MHz frequency is the most popular. Therefore, we aimed to investigate the adverse effect of exposure to 900 MHz EMF (1 h/day) on the cerebella of 12-week-old rats. We also evaluated the protective activity of luteolin (20 μg/kg/day) against possible biological change in the cerebellar tissues exposed to EMF. Twenty-four male wistar albino rats were randomly assigned into four group of six rats: Control, EMF, EMF+luteolin, luteolin. Serological and biochemical analyses, as well as histopathological examination were performed on all cerebellar samples. We found that SOD (superoxide dismutase) level was significantly increased in the EMF group compared to the control group (p < 0.05). To the contrary, decreased SOD activity was detected in the EMF+luteolin group compared to control group (p < 0.05). The total number of Purkinje and granular cells was significantly decreased in the EMF group compared to the control group (p < 0.05). In the EMF+luteolin group, the total number of Purkinje and granular cells was significantly higher than the EMF group (p < 0.05). Histopathological evaluation also showed destructive damage to the architectures of cerebellar tissues. Our results suggest that exposure to EMF may cause cellular damage to the rat cerebellum. Further, the improvement of cerebellar damage may have resulted from antioxidant efficacy of luteolin by alleviating oxidative stress. pubmed.ncbi.nlm.nih.gov

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

mixed

Population

12-week-old adult male Wistar albino rats

Sample size

Exposure

RF mobile phone (GSM) · 900 MHz · 1 h/day

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

Rats exposed to 900 MHz EMF (1 h/day) showed increased SOD in the EMF group versus control and decreased numbers of Purkinje and granular cells, with histopathological damage to cerebellar tissue architecture. In the EMF+luteolin group, Purkinje and granular cell numbers were higher than in the EMF-only group, and SOD activity was decreased compared with control.

Outcomes measured

Cerebellar histopathology/architecture
Purkinje cell count
Granular cell count
SOD (superoxide dismutase) level/activity
Serological and biochemical measures (unspecified)

Limitations

No SAR or exposure intensity reported in abstract
Small group sizes (n=6 per group)
Exposure duration described only as 1 h/day; total study duration not stated
Details of serological/biochemical analyses not specified in abstract

Suggested hubs

mobile-phones-rf (0.9)
Study examines 900 MHz GSM (cell phone) EMF exposure effects.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": "mobile phone (GSM)",
        "frequency_mhz": 900,
        "sar_wkg": null,
        "duration": "1 h/day"
    },
    "population": "12-week-old adult male Wistar albino rats",
    "sample_size": 24,
    "outcomes": [
        "Cerebellar histopathology/architecture",
        "Purkinje cell count",
        "Granular cell count",
        "SOD (superoxide dismutase) level/activity",
        "Serological and biochemical measures (unspecified)"
    ],
    "main_findings": "Rats exposed to 900 MHz EMF (1 h/day) showed increased SOD in the EMF group versus control and decreased numbers of Purkinje and granular cells, with histopathological damage to cerebellar tissue architecture. In the EMF+luteolin group, Purkinje and granular cell numbers were higher than in the EMF-only group, and SOD activity was decreased compared with control.",
    "effect_direction": "mixed",
    "limitations": [
        "No SAR or exposure intensity reported in abstract",
        "Small group sizes (n=6 per group)",
        "Exposure duration described only as 1 h/day; total study duration not stated",
        "Details of serological/biochemical analyses not specified in abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "900 MHz",
        "GSM",
        "cell phone",
        "electromagnetic field",
        "cerebellum",
        "Purkinje cells",
        "granular cells",
        "oxidative stress",
        "SOD",
        "luteolin",
        "rat"
    ],
    "suggested_hubs": [
        {
            "slug": "mobile-phones-rf",
            "weight": 0.90000000000000002220446049250313080847263336181640625,
            "reason": "Study examines 900 MHz GSM (cell phone) EMF exposure effects."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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