Neurotoxic effects of 3.5 GHz GSM-like RF exposure on cultured DRG neurons: a mechanistic insight into oxidative and apoptotic pathways
Research
RF Safe Research Library
Jan 1, 2026
This in vitro study examined strictly non-thermal, GSM-like 3.5 GHz RF-EMF exposure in cultured mouse dorsal root ganglion neurons for 1–24 hours. The authors report time-dependent reductions in cell viability alongside increased ROS and changes consistent with mitochondria-mediated apoptosis (e.g., Bax/caspase-3 up,…
Effect of dual RF-EMF and pulsed magnetic field exposure on eNOS expression and histological integrity in male rat reproductive tissues.
Research
RF Safe Research Library
Jan 1, 2026
This rat study examined combined RF-EMF and pulsed magnetic field exposure across multiple dosing schedules up to one month, assessing reproductive and related tissues with RT-qPCR, histopathology, and immunohistochemistry. The authors report increased eNOS expression with minimal VEGF change and generally preserved…
The effect of alpha-lipoic acid on liver damage induced by extremely low-frequency electromagnetic fields in a rat model
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RF Safe Research Library
Jan 1, 2025
This rat study assessed whether alpha-lipoic acid (ALA) modifies liver effects from extremely low-frequency magnetic field (ELF-MF) exposure. ELF-MF exposure (2 mT, 4 hours/day for 30 days) was associated with increased liver pathology and higher apoptosis markers (TUNEL, caspase-3) compared with other groups. ALA…
Prophylactic Effects of Radiofrequency Electromagnetic Field on Pulmonary Ischemia-Reperfusion via HIF-1α/eNOS Pathway and BCL2/BAX Signaling.
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RF Safe Research Library
Jan 1, 2025
This animal study tested whether RF-EMF exposure modifies lung ischemia-reperfusion injury in male Wistar rats. IR increased histologic injury, inflammatory/apoptotic markers, oxidative stress indices, and Hif-1α/eNOS/BAX while decreasing BCL2. The IR + RF-EMF group reportedly improved across measured parameters, and…
The Extremely-Low-Frequency Electromagnetic Field Affects Apoptosis and Oxidative-Stress-Related Genes and Proteins in the Porcine Endometrium-An In Vitro Study.
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RF Safe Research Library
Jan 1, 2024
This in vitro study exposed porcine endometrial slices collected during the peri-implantation period to a 50 Hz extremely-low-frequency electromagnetic field for 2 hours. The authors report decreased CASP7 and increased NOS3/eNOS mRNA and protein abundance after exposure, along with increases in additional…
Impact of ketamine administration on chronic unpredictable stress-induced rat model of depression during extremely low-frequency electromagnetic field exposure: Behavioral, histological and molecular study.
Research
RF Safe Research Library
Jan 1, 2023
This animal study evaluated ketamine administration combined with extremely low-frequency electromagnetic field (ELF-EMF) exposure in a chronic unpredictable stress (CUS) rat model. The authors report that the combined treatment increased depression-like behavior and neuronal degeneration, reduced GFAP(+) cells in…
The guardians of germ cells; Sertoli-derived exosomes against electromagnetic field-induced oxidative stress in mouse spermatogonial stem cells.
Research
RF Safe Research Library
Jan 1, 2021
This in vitro study exposed mouse spermatogonial stem cells to 50 Hz EMF (2.5 mT; 1 h/day for 5 days) and assessed oxidative stress and cell health outcomes. The authors report increased ROS and apoptosis with reduced antioxidant (catalase) expression, viability, and colonization after EMF exposure. Sertoli…
Effect of 900-MHz Electromagnetic Field on the Cerebellum: A Histopathological Investigation.
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RF Safe Research Library
Jan 1, 2018
This animal study evaluated histopathological effects of 900-MHz RF-EMF exposure on the rat cerebellum. The exposed group showed intense caspase-3 expression in Purkinje and granular cells and histological changes consistent with apoptosis. Cerebellar layer thickness appeared reduced in exposed animals, although…
Selenium supplementation ameliorates electromagnetic field-induced oxidative stress in the HEK293 cells.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study examined whether selenium supplementation modifies oxidative stress and apoptosis markers in HEK293 cells exposed to 2.4 GHz EMF. The authors report that EMF exposure increased lipid peroxidation (MDA) and apoptosis-related markers while decreasing antioxidant enzyme activities and bcl-2 versus…
2.45 GHz microwave radiation induced oxidative and nitrosative stress mediated testicular apoptosis: Involvement of a p53 dependent bax-caspase-3 mediated pathway.
Research
RF Safe Research Library
Jan 1, 2018
This animal study exposed 12-week-old male mice to 2.45 GHz continuous-wave microwave radiation (average power density 0.0248 mW/cm; whole-body SAR 0.0146 W/kg) for 2 hours/day over 15, 30, or 60 days. The authors evaluated testicular histology, testosterone, oxidative/nitrosative stress markers, antioxidant enzymes,…
Effects of radiofrequency exposure emitted from a GSM mobile phone on proliferation, differentiation, and apoptosis of neural stem cells.
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RF Safe Research Library
Jan 1, 2017
This in vitro study evaluated adult murine neural stem cells exposed to GSM 900-MHz radiofrequency emissions from a mobile phone across different exposure durations. The authors report significant decreases in neurosphere number/size and neuronal differentiation with increasing exposure duration. They report no…
Cytotoxicity of temozolomide on human glioblastoma cells is enhanced by the concomitant exposure to an extremely low-frequency electromagnetic field (100Hz, 100G).
Research
RF Safe Research Library
Jan 1, 2017
This in vitro study tested whether an extremely low-frequency EMF (100 Hz, 100 G) could enhance temozolomide cytotoxicity in human glioma cell lines (U87 and T98G). The authors report that combined EMF and temozolomide increased apoptosis relative to either treatment alone and was accompanied by changes in…
Effects of Wi-Fi (2.45 GHz) Exposure on Apoptosis, Sperm Parameters and Testicular Histomorphometry in Rats: A Time Course Study
Research
RF Safe Research Library
Jan 1, 2015
This animal experimental study exposed male Wistar rats to 2.45 GHz Wi-Fi radiation for 1 or 7 hours per day over two months and compared them with unexposed controls. The abstract reports time-dependent decreases in sperm parameters alongside increased apoptotic markers (apoptosis-positive cells and caspase-3…
The effect of exposure of rats during prenatal period to radiation spreading from mobile phones on renal development.
Research
RF Safe Research Library
Jan 1, 2015
This animal study exposed pregnant Sprague-Dawley rats to a 900 MHz electromagnetic field during the first 20 days of pregnancy and assessed prenatal renal development. The exposed group showed reported histopathological kidney changes and increased caspase-3 staining suggestive of higher apoptosis compared with…