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10 posts

Filters: tag: carcinogenicity Clear

On exposure-response interpretation and evidence synthesis in low-intensity RF-EMF research

Research RF Safe Research Library Jan 1, 2026

This paper presents a methodological discussion about how to interpret exposure-response patterns and synthesize evidence in low-intensity RF-EMF research, focusing on animal cancer bioassays. It references an exchange around a systematic review on RF-EMF and cancer in experimental animals and critiques/considers approaches to statistical inference and evidence synthesis. The authors emphasize that methodological choices can materially influence carcinogenic hazard identification and argue for rigorous, evidence-based analysis in risk assessment.

The International Collaborative Animal Study of Mobile Phone Radiofrequency Radiation Carcinogenicity and Genotoxicity: The Japanese Study

Research RF Safe Research Library Jan 1, 2026

This international collaborative animal study (Japanese arm) evaluated carcinogenicity and genotoxicity in male Sprague Dawley rats exposed long-term to 900 MHz CDMA-modulated RF-EMFs at 4 W/kg whole-body SAR. The abstract reports no statistically significant increases in neoplastic or non-neoplastic lesions in major organs and no evidence of genotoxicity on comet or micronucleus testing. The authors conclude the findings provide strong evidence of no reproducible carcinogenic or genotoxic effects under the studied conditions.

Adverse Effects of Electromagnetic Fields on The Central Nervous System: A Review

Research RF Safe Research Library Jan 1, 2025

This review argues that EMF exposure is associated in the literature with several adverse central nervous system outcomes, including blood-brain barrier disruption, oxidative stress, neurotransmitter changes, cognitive effects, and neurodevelopmental impacts. It reports that evidence on EMFs and brain tumors is conflicting, while noting WHO’s classification of radiofrequency EMFs as possibly carcinogenic to humans. The authors highlight prenatal and childhood periods as potentially more vulnerable and call for more standardized long-term and mechanistic research to guide public health policy.

Methodologically solid and analytically rigorous: the evaluations of our systematic review on RF-EMF and animal cancer are reliable

Research RF Safe Research Library Jan 1, 2025

No abstract is available in the provided material. From the title, the article appears to defend or affirm the methodological rigor and reliability of evaluations in the authors' systematic review on RF-EMF exposure and animal cancer. Specific results regarding carcinogenic effects are not stated in the provided text.

NTP Lite: The Japan-Korea Collaborative RF Exposure Toxicity Project [Health Matters]

Research RF Safe Research Library Jan 1, 2025

This magazine article reviews the Japan-Korea "NTP Lite" RF animal toxicity collaboration and its relationship to prior NTP (2018) and Ramazzini Institute reports of RF-associated tumors in male rats. It notes NTP Lite used a single whole-body SAR of 4 W/kg and completed a two-year exposure phase in 2022, but final reporting is delayed with histopathology and genotoxicity work ongoing. The author highlights protocol harmonization across labs while raising concerns about unexplained animal deaths and physiological differences in exposed groups, and frames the broader evidence as supportive of RF-related cancer risk in laboratory animals.

Carcinogenicity of Radio-Frequency Radiation: Similarities and Differences Between Outcomes of Two Studies

Research RF Safe Research Library Jan 1, 2025

This review compares two epidemiologic studies of radio-frequency radiation (RFR) exposure among military personnel with overlapping patient groups. One study reported a statistically significant increase in cancer among exposed individuals, while the other did not, which the review attributes to a smaller sample size. The review highlights similar cancer patterns across both studies, including a high proportion of hematolymphoid cancers and earlier onset among exposed individuals, and interprets these similarities as evidence of carcinogenic effects.

Exposure to radiofrequency electromagnetic fields and IARC carcinogen assessment: Risk of Bias preliminary literature assessment for 10 key characteristics of human carcinogens

Research RF Safe Research Library Jan 1, 2025

This review examined experimental literature on whether RF-EMF exposures within ICNIRP (2020) limits affect IARC key characteristics of human carcinogens. It identified 159 articles and found that 38% of in vitro/in vivo measurements reported statistically significant effects, but higher study quality was associated with fewer reported effects and there was no consistent exposure-response pattern. The authors state that study diversity and generally poor quality prevent high-confidence conclusions for most key characteristics, while recommending replication of the few higher-quality positive findings under stringent standards.

Carcinogenicity of extremely low-frequency magnetic fields: A systematic review of animal studies

Research RF Safe Research Library Jan 1, 2025

This PRISMA-based systematic review evaluated 54 animal studies on the carcinogenicity of extremely low-frequency (ELF) magnetic fields. The authors report very little evidence that ELF magnetic fields alone are carcinogenic. Findings on co-carcinogenicity (ELF MFs combined with other agents) are inconclusive, and the review notes a clear indication of publication bias.

Effects of radiofrequency electromagnetic field exposure on cancer in laboratory animal studies, a systematic review

Research RF Safe Research Library Jan 1, 2025

This systematic review evaluated RF EMF exposure and cancer outcomes in experimental animals, including chronic cancer bioassays and tumor-promotion designs. Across 52 included studies, the authors report high certainty of evidence for increased malignant heart schwannomas and gliomas in male rats, and moderate certainty for increased risks of several other tumor types. Many other organ systems showed no or minimal evidence of carcinogenic effects, and the authors note challenges in translating animal findings to human risk assessment due to exposure and mechanistic uncertainties.

Toxicology and carcinogenesis studies in Sprague Dawley (Hsd:Sprague Dawley SD) rats exposed to whole-body radio frequency radiation at a frequency (900 MHz) and modulations (GSM and CDMA) used by cell phones

Research RF Safe Research Library Jan 1, 2018

This National Toxicology Program technical report describes 900 MHz whole-body RFR exposures (GSM and CDMA) in male and female Sprague Dawley rats from in utero through up to 2 years. The report concludes clear evidence of carcinogenic activity in males for both modulations based on malignant schwannoma of the heart, with malignant glioma of the brain also reported as related to exposure. In females, the report concludes equivocal evidence of carcinogenic activity for both modulations based on selected tumor outcomes, and genetic toxicology findings were mixed with some comet assay increases/equivocal results but negative micronucleus assays.

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