Effects of radiofrequency electromagnetic field exposure on cancer in laboratory animal studies, a systematic review

Key points

• The review included 52 animal studies, including 20 chronic cancer bioassays, and did not exclude studies based on risk-of-bias concerns.
• Meta-analysis was not performed because studies were heterogeneous across design, species/strain/sex, exposure characteristics, and outcomes.
• Most organ systems showed no or minimal evidence of RF-EMF exposure-related cancer outcomes in the included studies.
• For brain tumors, two chronic bioassays in male rats reported increased glial cell-derived neoplasms, with high certainty of evidence for increased glioma.
• For heart neoplasms, two bioassays reported statistically significant increases in malignant schwannomas in male rats, with high certainty of evidence.
• Moderate certainty of evidence was reported for lymphoma, with inconsistency between two chronic bioassays not plausibly explainable.
• Moderate certainty of evidence was reported for adrenal pheochromocytoma, but findings were not dose-dependent compared with sham controls.
• Moderate certainty of evidence was also reported for hepatoblastomas and for lung neoplasms, including one chronic bioassay with a statistically significant positive trend.

Referenced studies & papers

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