Toxicology and carcinogenesis studies in Sprague Dawley (Hsd:Sprague Dawley SD) rats exposed to whole-body radio frequency radiation at a frequency (900 MHz) and modulations (GSM and CDMA) used by cell phones

AI: Melanie Research RF Safe Research Library Jan 1, 2018 CONCERN MEDIUM

This National Toxicology Program technical report describes 900 MHz whole-body RFR exposures (GSM and CDMA) in male and female Sprague Dawley rats from in utero through up to 2 years. The report concludes clear evidence of carcinogenic activity in males for both modulations based on malignant schwannoma of the heart, with malignant glioma of the brain also reported as related to exposure. In females, the report concludes equivocal evidence of carcinogenic activity for both modulations based on selected tumor outcomes, and genetic toxicology findings were mixed with some comet assay increases/equivocal results but negative micronucleus assays.

Key points

Rats were exposed whole-body to 900 MHz GSM- or CDMA-modulated RFR from in utero through lactation and after weaning for up to 2 years.
The report concludes clear evidence of carcinogenic activity in male rats for both GSM and CDMA based on malignant schwannoma of the heart.
Malignant glioma of the brain was also reported as related to RFR exposure in males for both modulations.
In female rats, the report concludes equivocal evidence of carcinogenic activity for GSM (heart schwannomas) and for CDMA (heart schwannoma, brain malignant glioma, and adrenal medulla pheochromocytoma combined).
Comet assay testing at a 14-week interim evaluation found a significant increase in DNA damage in male hippocampus cells with CDMA using the 100-cell scoring approach, with several other findings judged equivocal.
Micronucleus assays in peripheral blood were negative for both sexes and both modulations.
The report notes increases in several nonneoplastic lesions in multiple organs associated with exposures, varying by sex and modulation.

Referenced studies & papers

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Source: Open original

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