Yang ZZ, Wu DW, Ding B, et al. Long-Term, Low-Level Microwave Radiation Impairs Learning and Memory via Synbindin: Molecular Basis and Underlying Mechanism. Biomed Environ Sci. 2022;35(6):552-557. doi:10.3967/bes2022.074.

Abstract

Yang ZZ, Wu DW, Ding B, et al. Long-Term, Low-Level Microwave Radiation Impairs Learning and Memory via Synbindin: Molecular Basis and Underlying Mechanism. Biomed Environ Sci. 2022;35(6):552-557. doi:10.3967/bes2022.074. No abstract. Open access paper: besjournal.com Summarily, the study found that long-term low-intensity 2,100 MHz microwave radiation reduced spatial learning and memory ability of mice by the following possible mechanisms: (1) neuron ultrastructure destruction caused by oxidative stress; (2) dendritic spine growth inhibition caused by decreased mRNA and protein expression level of Sbdn, pERK or pERK/ERK level, and transcription, synthesis and transport of synaptic proteins. This study for the first time revealed a good intensity-response relationship between Sbdn expression and microwave intensity, suggesting an important mediating role of Sbdn in microwave inhibiting learning and memory by the way of microwave decreasing the expression of Sbdn and its downstream signal molecule pERK/ERK and then reducing the density of dendritic spine. See the mechanism of long-term low-intensity microwave inhibiting learning and memory (Supplementary Figure S5, available in besjournal.com). This study is of great value for the establishment of limits, risk assessment and protection of microwave occupational exposure population, and also has important value for the health impact of 5G microwave exposure on the public.

AI evidence extraction

Main findings

Long-term low-intensity 2,100 MHz microwave radiation impaired spatial learning and memory in mice, likely via neuron ultrastructure damage from oxidative stress and inhibition of dendritic spine growth related to decreased Synbindin expression and downstream signaling (pERK/ERK).

Outcomes measured

• spatial learning ability
• memory ability
• neuron ultrastructure
• oxidative stress
• dendritic spine growth
• mRNA and protein expression of Synbindin (Sbdn)
• pERK/ERK levels
• synaptic protein transcription, synthesis, and transport

Limitations

• No abstract provided, only summary available
• Sample size and detailed methodology not stated
• Findings based on animal model, limiting direct human applicability

Suggested hubs

• occupational-exposure (0.8)
  Study relevance to microwave occupational exposure population risk assessment and protection.
• 5g-policy (0.7)
  Study discusses health impact of 5G microwave exposure on the public.

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    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 2100,
        "sar_wkg": null,
        "duration": "long-term, low-level"
    },
    "population": "mice",
    "sample_size": null,
    "outcomes": [
        "spatial learning ability",
        "memory ability",
        "neuron ultrastructure",
        "oxidative stress",
        "dendritic spine growth",
        "mRNA and protein expression of Synbindin (Sbdn)",
        "pERK/ERK levels",
        "synaptic protein transcription, synthesis, and transport"
    ],
    "main_findings": "Long-term low-intensity 2,100 MHz microwave radiation impaired spatial learning and memory in mice, likely via neuron ultrastructure damage from oxidative stress and inhibition of dendritic spine growth related to decreased Synbindin expression and downstream signaling (pERK/ERK).",
    "effect_direction": "harm",
    "limitations": [
        "No abstract provided, only summary available",
        "Sample size and detailed methodology not stated",
        "Findings based on animal model, limiting direct human applicability"
    ],
    "evidence_strength": "moderate",
    "confidence": 0.6999999999999999555910790149937383830547332763671875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "2.1 GHz",
        "learning impairment",
        "memory impairment",
        "Synbindin",
        "oxidative stress",
        "dendritic spine",
        "pERK",
        "animal study",
        "5G"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.8000000000000000444089209850062616169452667236328125,
            "reason": "Study relevance to microwave occupational exposure population risk assessment and protection."
        },
        {
            "slug": "5g-policy",
            "weight": 0.6999999999999999555910790149937383830547332763671875,
            "reason": "Study discusses health impact of 5G microwave exposure on the public."
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