Biochemical changes in rat brain exposed to low intensity 9.9 GHz microwave radiation.

PAPER pubmed Cell biochemistry and biophysics 2012 Animal study Effect: harm Evidence: Low

Read original paper → DOI: 10.1007/s12013-012-9344-3 PMID: 22426826 Evidence Lab

Abstract

Present study concerns with various biochemical changes in the developing rat brain exposed to 9.9 GHz (square wave modulated, 1 kHz) at power density 0.125 mW/cm(2) (specific absorption rate 1.0 W/kg) for 2 h/day for 35 days. Thirty days old male wistar rats were used for this present study. Each group consists of eight animals. After the exposure, biochemical assays such as calcium ion efflux, calcium-dependent protein kinase (PKC), and ornithine decarboxylase (ODC) were performed on the brain tissue. Results of this study reveal that chronic exposure of rat to microwave radiation alter the activity of certain enzymes. There was a significant increase in calcium ion efflux and the activity of ODC. On the other hand, there is a significant decrease in PKC activity. Since these enzymes are related to growth, any alteration may lead to affect functioning of the brain and its development.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Thirty-day-old male Wistar rats (developing rat brain)

Sample size

Exposure

microwave · 9900 MHz · 1 W/kg · 2 h/day for 35 days

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

Developing rat brains exposed to 9.9 GHz microwave radiation (square wave modulated at 1 kHz) showed significant increases in calcium ion efflux and ODC activity, and a significant decrease in PKC activity compared with controls.

Outcomes measured

Calcium ion efflux
Calcium-dependent protein kinase (PKC) activity
Ornithine decarboxylase (ODC) activity

Limitations

Only male Wistar rats were studied
Small group size (8 animals per group)
Outcomes limited to selected biochemical assays; no behavioral or functional endpoints reported in abstract
Exposure conditions are specific (9.9 GHz, square-wave modulated at 1 kHz; power density 0.125 mW/cm^2; SAR 1.0 W/kg), limiting generalizability

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 9900,
        "sar_wkg": 1,
        "duration": "2 h/day for 35 days"
    },
    "population": "Thirty-day-old male Wistar rats (developing rat brain)",
    "sample_size": 16,
    "outcomes": [
        "Calcium ion efflux",
        "Calcium-dependent protein kinase (PKC) activity",
        "Ornithine decarboxylase (ODC) activity"
    ],
    "main_findings": "Developing rat brains exposed to 9.9 GHz microwave radiation (square wave modulated at 1 kHz) showed significant increases in calcium ion efflux and ODC activity, and a significant decrease in PKC activity compared with controls.",
    "effect_direction": "harm",
    "limitations": [
        "Only male Wistar rats were studied",
        "Small group size (8 animals per group)",
        "Outcomes limited to selected biochemical assays; no behavioral or functional endpoints reported in abstract",
        "Exposure conditions are specific (9.9 GHz, square-wave modulated at 1 kHz; power density 0.125 mW/cm^2; SAR 1.0 W/kg), limiting generalizability"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "rat brain",
        "microwave radiation",
        "9.9 GHz",
        "square wave modulation",
        "1 kHz",
        "SAR 1.0 W/kg",
        "power density 0.125 mW/cm^2",
        "calcium efflux",
        "PKC",
        "ornithine decarboxylase",
        "biochemical changes",
        "development"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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