Ibuprofen effects on behavioral thermoregulation with microwave radiation in albino rats.

Abstract

This study determined whether ibuprofen causes a disruptive behavior pattern similar to aspirin yet contrary to acetaminophen regarding thermoregulatory effects. 8 Sprague-Dawley rats (3 males and 5 females) were drawn from a population of rats which had been conditioned to press a lever for food reinforcement in an undergraduate course in operant conditioning. Animals were conditioned in a refrigerated Skinner Box on a fixed-interval 2-min. (FI-2 min.) schedule of microwave radiation (5 sec. of radiation per exposure occasion) in a repeated-measures reversal (within-subjects) design. The rats were injected intraperitoneally with doses of ibuprofen in amounts of 10-50 mg/kg or methyl-cellulose control vehicle of equal volume over 8-hr. daily sessions. A multivariate analysis of variance showed significant differences due to doses (mg/kg) of ibuprofen for number of microwave heat reinforcers per hour and rate of responding (ns) both measures of which were significantly higher during the first 2 hours of the session. Comparative differences in behavioral thermoregulation in humans reflect the likelihood of underlying biochemical mechanisms based on research by Murphy, Badia, Myers, Boecker, and Wright in 1994.

AI evidence extraction

Main findings

In a within-subjects reversal design, ibuprofen dose (10–50 mg/kg, i.p.) was associated with significant differences in number of microwave heat reinforcers per hour and rate of responding, with both measures significantly higher during the first 2 hours of the session.

Outcomes measured

• behavioral thermoregulation
• number of microwave heat reinforcers per hour
• rate of responding

Limitations

• Very small sample size (n=8)
• Microwave exposure frequency and dosimetry (e.g., SAR) not reported in abstract
• Outcome measures are behavioral/operant metrics; generalizability to other endpoints not addressed in abstract
• Details of statistical results (effect sizes, exact p-values) not provided in abstract

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "5 sec of radiation per exposure occasion; FI-2 min schedule; 8-hr daily sessions"
    },
    "population": "Sprague-Dawley albino rats (3 males, 5 females)",
    "sample_size": 8,
    "outcomes": [
        "behavioral thermoregulation",
        "number of microwave heat reinforcers per hour",
        "rate of responding"
    ],
    "main_findings": "In a within-subjects reversal design, ibuprofen dose (10–50 mg/kg, i.p.) was associated with significant differences in number of microwave heat reinforcers per hour and rate of responding, with both measures significantly higher during the first 2 hours of the session.",
    "effect_direction": "mixed",
    "limitations": [
        "Very small sample size (n=8)",
        "Microwave exposure frequency and dosimetry (e.g., SAR) not reported in abstract",
        "Outcome measures are behavioral/operant metrics; generalizability to other endpoints not addressed in abstract",
        "Details of statistical results (effect sizes, exact p-values) not provided in abstract"
    ],
    "evidence_strength": "very_low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "behavioral thermoregulation",
        "ibuprofen",
        "operant conditioning",
        "rats",
        "Skinner box",
        "fixed-interval schedule"
    ],
    "suggested_hubs": []
}

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