In situ fixation of the spinal cord using microwave radiation.

PAPER pubmed Journal of neurosurgery 1988 Other Effect: benefit Evidence: Insufficient

Read original paper → DOI: 10.3171/jns.1988.69.5.0719 PMID: 3183733 Evidence Lab

Abstract

Due to its investiture with bone, the spinal cord can be difficult to study anatomically and histologically. Tissue degradation during immersion fixation or mechanical trauma during extraction of unfixed tissue often produces confusing artifacts. Perfusion fixation eliminates many of these problems, but it is a slow, tedious, and technically demanding procedure. This report demonstrates that microwave irradiation of the spinal cord before its removal from the spine is a rapid and easy method of tissue fixation with an absence of artifacts comparable to that with perfusion fixation.

AI evidence extraction

At a glance

Study type

Other

Effect direction

benefit

Population

—

Sample size

—

Exposure

microwave microwave irradiation (tissue fixation)

Evidence strength

Insufficient

Confidence: 66% · Peer-reviewed: yes

Main findings

The report states that microwave irradiation of the spinal cord before removal from the spine provides a rapid and easy method of tissue fixation, with an absence of artifacts comparable to perfusion fixation.

Outcomes measured

quality of spinal cord tissue fixation
presence/absence of histological artifacts
tissue degradation during fixation
mechanical trauma artifacts during extraction

Limitations

No sample size reported in abstract.
No microwave exposure parameters (frequency, power/SAR, duration) reported in abstract.
Study design details and quantitative outcome measures not described in abstract.

View raw extracted JSON

{
    "study_type": "other",
    "exposure": {
        "band": "microwave",
        "source": "microwave irradiation (tissue fixation)",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": null,
    "sample_size": null,
    "outcomes": [
        "quality of spinal cord tissue fixation",
        "presence/absence of histological artifacts",
        "tissue degradation during fixation",
        "mechanical trauma artifacts during extraction"
    ],
    "main_findings": "The report states that microwave irradiation of the spinal cord before removal from the spine provides a rapid and easy method of tissue fixation, with an absence of artifacts comparable to perfusion fixation.",
    "effect_direction": "benefit",
    "limitations": [
        "No sample size reported in abstract.",
        "No microwave exposure parameters (frequency, power/SAR, duration) reported in abstract.",
        "Study design details and quantitative outcome measures not described in abstract."
    ],
    "evidence_strength": "insufficient",
    "confidence": 0.66000000000000003108624468950438313186168670654296875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave irradiation",
        "spinal cord",
        "in situ fixation",
        "tissue fixation",
        "histology",
        "artifacts",
        "perfusion fixation"
    ],
    "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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