Behavioral effects of chlorpromazine and diazepam combined with low-level microwaves.

PAPER pubmed Neurobehavioral toxicology 1980 Animal study Effect: no_effect Evidence: Low

Read original paper → PMID: 7290309 Evidence Lab

Abstract

Previous research findings on the interaction between drugs and microwave radiation were extended to chlorpromazine and to diazepam. The drugs were combined with a 1 mW/cm2 pulsed microwave field (2.8 GHz) and effects were measured on a fixed interval (FI 1) schedule of food reinforcement with rats. Dose-effect functions with and without sham irradiation were established for each drug. At effective doses chlorpromazine consistently decreased rate of responding and reduced with-interval response patterning. Low to moderate doses of diazepam produced little change or increases in response rate, and higher doses produced a decline in response rate. Response patterning within intervals was reduced by increasing doses of diazepam. The animals were exposed to the microwave field alone before test sessions combining the drugs with microwave radiation. Microwave exposure alone did not affect FI performance. Microwave radiation in combination with either drug did not produce any alterations in the dose-effect functions.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

no_effect

Population

rats

Sample size

—

Exposure

microwave · 2800 MHz

Evidence strength

Low

Confidence: 50% · Peer-reviewed: yes

Main findings

Microwave exposure alone did not affect fixed interval performance in rats. Chlorpromazine decreased response rate and patterning, diazepam had dose-dependent effects on response rate and reduced patterning. Combining microwaves with either drug did not alter the drugs' dose-effect functions.

Outcomes measured

rate of responding
response patterning on fixed interval schedule

Limitations

No sample size reported
Only one microwave power density tested
Only two drugs tested
Animal study limits direct human applicability

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 2800,
        "sar_wkg": null,
        "duration": null
    },
    "population": "rats",
    "sample_size": null,
    "outcomes": [
        "rate of responding",
        "response patterning on fixed interval schedule"
    ],
    "main_findings": "Microwave exposure alone did not affect fixed interval performance in rats. Chlorpromazine decreased response rate and patterning, diazepam had dose-dependent effects on response rate and reduced patterning. Combining microwaves with either drug did not alter the drugs' dose-effect functions.",
    "effect_direction": "no_effect",
    "limitations": [
        "No sample size reported",
        "Only one microwave power density tested",
        "Only two drugs tested",
        "Animal study limits direct human applicability"
    ],
    "evidence_strength": "low",
    "confidence": 0.5,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "chlorpromazine",
        "diazepam",
        "microwave radiation",
        "behavioral effects",
        "rats",
        "fixed interval schedule"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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