[Ultracytochemical changes in the brain and liver in exposure to low-intensity nonionizing microwave radiation].

Abstract

The morphological (including electron microscopy, histochemistry, morphometry) and biochemical methods were used in experiments on 478 white rats to determine the content of glycogen, tigroid substance, RNA, DNA and activity of the enzymes (SDH, MDH, LDH, G-6-PDH, phosphorylase) in intact animals after and during exposure to nonionizing microwave radiation (NMR), 30 and 60 days after the rehabilitation period, as well as after physiological exposures (hypoxia and NMR of higher intensity). It was disclosed that repeated exposure to little doses of NMR alters the structural and functional bases of the mechanisms that regulate cell metabolism, produces conformational changes in the chemical substances and thus exerts a damaging action on the delicate cell structures; redistributes the action on the pathways of energy formation at the expense of compensatory protein synthesis and the increase enzymatic systems; increases the resistance to hypoxia and action of NMR of higher intensities.

AI evidence extraction

Main findings

In experiments on 478 white rats, repeated exposure to low doses of nonionizing microwave radiation was reported to alter structural and functional bases regulating cell metabolism and to exert a damaging action on delicate cell structures, with changes described as conformational changes in chemical substances and redistribution of energy-formation pathways with compensatory protein synthesis and increased enzymatic systems. The authors also report increased resistance to hypoxia and to higher-intensity microwave exposure.

Outcomes measured

• Brain and liver ultracytochemical/morphological changes (electron microscopy, histochemistry, morphometry)
• Glycogen content
• Tigroid substance content
• RNA content
• DNA content
• Enzyme activity: SDH, MDH, LDH, G-6-PDH, phosphorylase
• Resistance to hypoxia
• Response to higher-intensity microwave exposure

Limitations

• Exposure parameters (frequency, intensity/SAR, and detailed schedule) not reported in the abstract
• Outcome results are described qualitatively; no quantitative effect sizes or statistical details provided
• Unclear how brain vs liver findings differed and which specific measures changed

Suggested hubs

• animal-studies (0.9)
  Experimental study in rats assessing biological effects of microwave radiation.

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "during exposure; 30 and 60 days after a rehabilitation period (exact exposure schedule not stated)"
    },
    "population": "White rats",
    "sample_size": 478,
    "outcomes": [
        "Brain and liver ultracytochemical/morphological changes (electron microscopy, histochemistry, morphometry)",
        "Glycogen content",
        "Tigroid substance content",
        "RNA content",
        "DNA content",
        "Enzyme activity: SDH, MDH, LDH, G-6-PDH, phosphorylase",
        "Resistance to hypoxia",
        "Response to higher-intensity microwave exposure"
    ],
    "main_findings": "In experiments on 478 white rats, repeated exposure to low doses of nonionizing microwave radiation was reported to alter structural and functional bases regulating cell metabolism and to exert a damaging action on delicate cell structures, with changes described as conformational changes in chemical substances and redistribution of energy-formation pathways with compensatory protein synthesis and increased enzymatic systems. The authors also report increased resistance to hypoxia and to higher-intensity microwave exposure.",
    "effect_direction": "mixed",
    "limitations": [
        "Exposure parameters (frequency, intensity/SAR, and detailed schedule) not reported in the abstract",
        "Outcome results are described qualitatively; no quantitative effect sizes or statistical details provided",
        "Unclear how brain vs liver findings differed and which specific measures changed"
    ],
    "evidence_strength": "low",
    "confidence": 0.66000000000000003108624468950438313186168670654296875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "nonionizing microwave radiation",
        "low-intensity",
        "rats",
        "brain",
        "liver",
        "electron microscopy",
        "histochemistry",
        "morphometry",
        "glycogen",
        "RNA",
        "DNA",
        "SDH",
        "MDH",
        "LDH",
        "G-6-PDH",
        "phosphorylase",
        "hypoxia"
    ],
    "suggested_hubs": [
        {
            "slug": "animal-studies",
            "weight": 0.90000000000000002220446049250313080847263336181640625,
            "reason": "Experimental study in rats assessing biological effects of microwave radiation."
        }
    ]
}

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