Cellular and Molecular Effects of Magnetic Fields

PAPER manual International Journal of Molecular Sciences 2024 Review Effect: mixed Evidence: Insufficient

Read original paper → DOI: 10.3390/ijms25168973 Evidence Lab

Abstract

Cellular and Molecular Effects of Magnetic Fields Tota M, Jonderko L, Witek J, Novickij V, Kulbacka J. Cellular and Molecular Effects of Magnetic Fields. Int J Mol Sci. 2024 Aug 17;25(16):8973. doi: 10.3390/ijms25168973. Abstract Recently, magnetic fields (MFs) have received major attention due to their potential therapeutic applications and biological effects. This review provides a comprehensive analysis of the cellular and molecular impacts of MFs, with a focus on both in vitro and in vivo studies. We investigate the mechanisms by which MFs influence cell behavior, including modifications in gene expression, protein synthesis, and cellular signaling pathways. The interaction of MFs with cellular components such as ion channels, membranes, and the cytoskeleton is analyzed, along with their effects on cellular processes like proliferation, differentiation, and apoptosis. Molecular insights are offered into how MFs modulate oxidative stress and inflammatory responses, which are pivotal in various pathological conditions. Furthermore, we explore the therapeutic potential of MFs in regenerative medicine, cancer treatment, and neurodegenerative diseases. By synthesizing current findings, this article aims to elucidate the complex bioeffects of MFs, thereby facilitating their optimized application in medical and biotechnological fields. Open access paper: mdpi.com

AI evidence extraction

At a glance

Study type

Review

Effect direction

mixed

Population

—

Sample size

—

Exposure

other

Evidence strength

Insufficient

Confidence: 74% · Peer-reviewed: yes

Main findings

This review summarizes in vitro and in vivo evidence that magnetic fields can influence cell behavior, including changes in gene expression, protein synthesis, and signaling pathways, and may interact with ion channels, membranes, and the cytoskeleton. It also describes reported effects on proliferation, differentiation, apoptosis, oxidative stress, and inflammatory responses, and discusses potential therapeutic applications in regenerative medicine, cancer, and neurodegenerative diseases.

Outcomes measured

gene expression
protein synthesis
cellular signaling pathways
ion channel interactions
membrane interactions
cytoskeleton interactions
cell proliferation
cell differentiation
apoptosis
oxidative stress
inflammatory responses
therapeutic applications (regenerative medicine, cancer treatment, neurodegenerative diseases)

View raw extracted JSON

{
    "study_type": "review",
    "exposure": {
        "band": null,
        "source": "other",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": null,
    "sample_size": null,
    "outcomes": [
        "gene expression",
        "protein synthesis",
        "cellular signaling pathways",
        "ion channel interactions",
        "membrane interactions",
        "cytoskeleton interactions",
        "cell proliferation",
        "cell differentiation",
        "apoptosis",
        "oxidative stress",
        "inflammatory responses",
        "therapeutic applications (regenerative medicine, cancer treatment, neurodegenerative diseases)"
    ],
    "main_findings": "This review summarizes in vitro and in vivo evidence that magnetic fields can influence cell behavior, including changes in gene expression, protein synthesis, and signaling pathways, and may interact with ion channels, membranes, and the cytoskeleton. It also describes reported effects on proliferation, differentiation, apoptosis, oxidative stress, and inflammatory responses, and discusses potential therapeutic applications in regenerative medicine, cancer, and neurodegenerative diseases.",
    "effect_direction": "mixed",
    "limitations": [],
    "evidence_strength": "insufficient",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "magnetic fields",
        "cellular effects",
        "molecular effects",
        "in vitro",
        "in vivo",
        "gene expression",
        "protein synthesis",
        "signaling pathways",
        "ion channels",
        "membranes",
        "cytoskeleton",
        "proliferation",
        "differentiation",
        "apoptosis",
        "oxidative stress",
        "inflammation",
        "regenerative medicine",
        "cancer",
        "neurodegenerative diseases"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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