The effect of electromagnetic field stimulation on corticosteroids-inhibited intestinal wound healing.

PAPER pubmed The Tokai journal of experimental and clinical medicine 1993 Animal study Effect: benefit Evidence: Low

Read original paper → PMID: 7940606 Evidence Lab

Abstract

Electromagnetic field (EMF) stimulation has been used successfully in the clinical setting to promote healing of ununited fractures. In a few studies, EMF stimulation enhanced soft tissue healing. To investigate the effect of EMF stimulation on intestinal wound healing in normal rats and in those treated with corticosteroids, 80 Wistar rats received twice-daily injections of either saline dexamethasone (0.1 mg/kg/day for 2 weeks. Animals then underwent creation of single-layer, inverting small intestine anastomoses. All injections were continued postoperatively. Animals were grouped as intestinal anastomoses; intestinal anastomoses plus EMF stimulation; intestinal anastomoses plus dexamethasone; and intestinal anastomoses plus dexamethasone plus EMF. On postoperative days 7 and 14, the anastomosed intestines were removed and the tensile strength (TS) and hydroxyproline (OH-P) contents measured. EMF stimulation significantly increased intestinal wound healing in normal animals by the 7th and 14th day. Corticosteroids significantly impaired the healing of the small intestine anastomoses, with decreased TS and OH-P contents after the first and second weeks. However, EMF stimulation significantly reversed this inhibitory effect.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

benefit

Population

Wistar rats with small intestine anastomoses; some treated with dexamethasone (0.1 mg/kg/day for 2 weeks, continued postoperatively)

Sample size

Exposure

electromagnetic field stimulation · postoperative EMF stimulation; outcomes assessed on postoperative days 7 and 14

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

EMF stimulation significantly increased intestinal wound healing in normal rats at postoperative days 7 and 14. Dexamethasone significantly impaired healing (decreased TS and OH-P), and EMF stimulation significantly reversed this inhibitory effect.

Outcomes measured

Intestinal wound healing
Tensile strength (TS) of anastomosis
Hydroxyproline (OH-P) content

Limitations

EMF exposure parameters (e.g., frequency, intensity, waveform) not reported in the abstract
Animal model; generalizability to humans not addressed
No details provided on randomization, blinding, or allocation concealment
Follow-up limited to postoperative days 7 and 14

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": null,
        "source": "electromagnetic field stimulation",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "postoperative EMF stimulation; outcomes assessed on postoperative days 7 and 14"
    },
    "population": "Wistar rats with small intestine anastomoses; some treated with dexamethasone (0.1 mg/kg/day for 2 weeks, continued postoperatively)",
    "sample_size": 80,
    "outcomes": [
        "Intestinal wound healing",
        "Tensile strength (TS) of anastomosis",
        "Hydroxyproline (OH-P) content"
    ],
    "main_findings": "EMF stimulation significantly increased intestinal wound healing in normal rats at postoperative days 7 and 14. Dexamethasone significantly impaired healing (decreased TS and OH-P), and EMF stimulation significantly reversed this inhibitory effect.",
    "effect_direction": "benefit",
    "limitations": [
        "EMF exposure parameters (e.g., frequency, intensity, waveform) not reported in the abstract",
        "Animal model; generalizability to humans not addressed",
        "No details provided on randomization, blinding, or allocation concealment",
        "Follow-up limited to postoperative days 7 and 14"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "electromagnetic field stimulation",
        "intestinal anastomosis",
        "wound healing",
        "dexamethasone",
        "corticosteroids",
        "tensile strength",
        "hydroxyproline",
        "rat"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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