[Effect of 900MHz electromagnetic fields on energy metabolism of cerebral cortical neurons in postnatal rat].

Abstract

OBJECTIVE: To investigate the effects of low intensity microwave (900MHz) electromagnetic fields (EMF) on energy metabolism of cerebral cortical neurons in postnatal rat. METHODS: Neurons were exposed to low intensity 900MHz continuous microwave EMF (9mW/cm2, SAR = 3.22mW/g) for 2 hours per day in 4 or 5 consecutive days and for 12 hours at a time. The authors chose cytochrome oxidase (CCO) as the biological end. RESULTS: The results of cytochemistry showed that compared to the sham-exposed, a significant decrease of cytochrome oxidase activity in neurons exposed for 2 hours per day and the neurons exposed for 12 hours to be immediately experimented (P < 0.001). CONCLUSION: Down-regulation of CCO should be classified as 'non-thermal effects'. Cumulated power effect were observed in neuronal response to the microwave. The influence on the CCO of the chosen microwave EMF could be recovered to some extent. The effects had no close relation between the first exposure and the cultured age of neurons.

AI evidence extraction

Main findings

Cytochemistry results indicated a significant decrease in cytochrome oxidase activity compared with sham-exposed neurons after exposure for 2 hours/day (4 or 5 consecutive days) and after 12 hours exposure when immediately tested (P < 0.001). The authors report the influence on CCO could be recovered to some extent and was not closely related to first exposure or cultured age of neurons.

Outcomes measured

• Cytochrome oxidase (CCO) activity
• Energy metabolism (via CCO as endpoint)

Limitations

• In vitro study (cultured neurons)
• Sample size not reported in abstract
• Limited outcome scope (CCO activity as the biological endpoint)
• Exposure conditions described as low intensity but thermal control details not provided in abstract

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "RF",
        "source": null,
        "frequency_mhz": 900,
        "sar_wkg": 0.0032200000000000002058075931898883936810307204723358154296875,
        "duration": "2 hours/day for 4 or 5 consecutive days; and 12 hours at a time"
    },
    "population": "Cerebral cortical neurons (postnatal rat; cultured)",
    "sample_size": null,
    "outcomes": [
        "Cytochrome oxidase (CCO) activity",
        "Energy metabolism (via CCO as endpoint)"
    ],
    "main_findings": "Cytochemistry results indicated a significant decrease in cytochrome oxidase activity compared with sham-exposed neurons after exposure for 2 hours/day (4 or 5 consecutive days) and after 12 hours exposure when immediately tested (P < 0.001). The authors report the influence on CCO could be recovered to some extent and was not closely related to first exposure or cultured age of neurons.",
    "effect_direction": "harm",
    "limitations": [
        "In vitro study (cultured neurons)",
        "Sample size not reported in abstract",
        "Limited outcome scope (CCO activity as the biological endpoint)",
        "Exposure conditions described as low intensity but thermal control details not provided in abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "900 MHz",
        "microwave",
        "RF EMF",
        "in vitro",
        "rat cortical neurons",
        "cytochrome oxidase",
        "CCO",
        "energy metabolism",
        "SAR"
    ],
    "suggested_hubs": []
}

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