Changes in hydroxyproline levels in electric field tissue interaction.

PAPER pubmed Indian journal of biochemistry & biophysics 1996 Animal study Effect: harm Evidence: Very low

Read original paper → PMID: 9219442 Evidence Lab

Abstract

Guinea pigs when exposed to external electric field (1.9 kV/m) for 9 hrs/day for 3 days registered rise in the levels of hydroxyproline in liver, lung and kidney, suggesting increased synthesis of collagen.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Guinea pigs

Sample size

—

Exposure

external electric field · 9 hrs/day for 3 days

Evidence strength

Very low

Confidence: 72% · Peer-reviewed: yes

Main findings

Guinea pigs exposed to an external electric field (1.9 kV/m) for 9 hours/day for 3 days showed increased hydroxyproline levels in liver, lung, and kidney. The authors suggest this indicates increased collagen synthesis.

Outcomes measured

Hydroxyproline levels in liver
Hydroxyproline levels in lung
Hydroxyproline levels in kidney
Collagen synthesis (suggested)

Limitations

Sample size not reported in abstract
No frequency or other exposure characterization beyond field strength provided
Outcome interpretation (collagen synthesis) is inferred from hydroxyproline changes

Suggested hubs

occupational-exposure (0.25)
Study involves exposure to an external electric field; could be relevant to electric-field exposure contexts, though no occupational setting is specified.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": null,
        "source": "external electric field",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "9 hrs/day for 3 days"
    },
    "population": "Guinea pigs",
    "sample_size": null,
    "outcomes": [
        "Hydroxyproline levels in liver",
        "Hydroxyproline levels in lung",
        "Hydroxyproline levels in kidney",
        "Collagen synthesis (suggested)"
    ],
    "main_findings": "Guinea pigs exposed to an external electric field (1.9 kV/m) for 9 hours/day for 3 days showed increased hydroxyproline levels in liver, lung, and kidney. The authors suggest this indicates increased collagen synthesis.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in abstract",
        "No frequency or other exposure characterization beyond field strength provided",
        "Outcome interpretation (collagen synthesis) is inferred from hydroxyproline changes"
    ],
    "evidence_strength": "very_low",
    "confidence": 0.7199999999999999733546474089962430298328399658203125,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "electric field",
        "guinea pig",
        "hydroxyproline",
        "collagen",
        "liver",
        "lung",
        "kidney"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.25,
            "reason": "Study involves exposure to an external electric field; could be relevant to electric-field exposure contexts, though no occupational setting is specified."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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