[Effects of low frequency pulsed electric field on insulin studied by fluorescent spectrum].

PAPER pubmed Guang pu xue yu guang pu fen xi = Guang pu 2001 In vitro study Effect: harm Evidence: Very low

Read original paper → PMID: 12947682 Evidence Lab

Abstract

Insulin, an intercellular signal molecular, plays a critical role in transferring life information. The studies on effects of pulsed electric fields on insulin molecular are meaningful for explaining the mechanism of biological effects of electromagnetic fields. The experiment results demonstrate that the conformation of insulin molecular has been altered by electric fields exposure for 30 minutes or by heat exposure for 50 hours. The results suggest that pulsed electric field exposure as heat exposure will after conformation of insulin molecular by breaking some hydrogen bonds and recombining another hydrogen bonds. The intercellular signal molecular may be an important target of electromagnetic fields.

AI evidence extraction

At a glance

Study type

In vitro study

Effect direction

harm

Population

—

Sample size

—

Exposure

ELF pulsed electric field · 30 minutes

Evidence strength

Very low

Confidence: 66% · Peer-reviewed: yes

Main findings

Experimental results reported that insulin molecular conformation was altered after 30 minutes of pulsed electric field exposure; heat exposure for 50 hours also altered conformation. The authors suggest the conformation change may involve breaking and recombining hydrogen bonds.

Outcomes measured

Insulin molecular conformation (fluorescence spectrum)
Hydrogen bond changes (breaking/recombining; inferred mechanism described)

Limitations

No exposure parameters beyond duration (e.g., field strength, pulse characteristics, frequency) reported in abstract
No sample size or replication details provided in abstract
In vitro molecular outcome; relevance to health outcomes not addressed in abstract

View raw extracted JSON

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "ELF",
        "source": "pulsed electric field",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "30 minutes"
    },
    "population": null,
    "sample_size": null,
    "outcomes": [
        "Insulin molecular conformation (fluorescence spectrum)",
        "Hydrogen bond changes (breaking/recombining; inferred mechanism described)"
    ],
    "main_findings": "Experimental results reported that insulin molecular conformation was altered after 30 minutes of pulsed electric field exposure; heat exposure for 50 hours also altered conformation. The authors suggest the conformation change may involve breaking and recombining hydrogen bonds.",
    "effect_direction": "harm",
    "limitations": [
        "No exposure parameters beyond duration (e.g., field strength, pulse characteristics, frequency) reported in abstract",
        "No sample size or replication details provided in abstract",
        "In vitro molecular outcome; relevance to health outcomes not addressed in abstract"
    ],
    "evidence_strength": "very_low",
    "confidence": 0.66000000000000003108624468950438313186168670654296875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "pulsed electric field",
        "low frequency",
        "insulin",
        "fluorescence spectrum",
        "protein conformation",
        "hydrogen bonds",
        "electromagnetic fields"
    ],
    "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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