Electrophysiological modeling study of ECG T-wave alternation caused by ultrahigh static magnetic fields.

Abstract

The goal of our research is try to explain the electrophysiological mechanisms of alternation in T-wave of ECG in ultrahigh static magnetic field (SMF). The magneto-hydrodynamics model study shows that ultrahigh SMF can induce reduction in the volume flow rate of the blood in human arota more than 10%, thus may lead to anoxia condition of acute ischemia. Using an ionic-based theoretical model of the cardiac ventricular cell, we simulate transmural heterogeneous suppression of the action potential plateau and action potential duration shortening in case of different anoxia degree. The results demonstrated that anoxia may produce a significant increase in the T-wave amplitude, which may be another mechanism for the influence of ultrahigh SMF to T-wave. This finding is consistent with experimental observation. This study suggests that one should strengthen the safety inspection of ECG in MRI scan and in other application of ultrahigh SMF.

AI evidence extraction

Main findings

A magneto-hydrodynamics model suggested that ultrahigh static magnetic fields could reduce blood volume flow rate in the human aorta by more than 10%, which the authors propose may lead to an anoxia condition of acute ischemia. Using an ionic-based ventricular cell model, simulations indicated that anoxia could increase T-wave amplitude and was presented as a possible mechanism contributing to T-wave effects observed under ultrahigh static magnetic fields.

Outcomes measured

• ECG T-wave alternation
• T-wave amplitude
• blood volume flow rate in aorta
• anoxia/acute ischemia (modeled)
• ventricular action potential plateau suppression
• action potential duration shortening

Limitations

• Modeling study (magneto-hydrodynamics and theoretical ionic-based cell simulations) rather than direct human or animal exposure measurements
• Exposure level described as 'ultrahigh' static magnetic field without quantitative field strength in the abstract
• Causal pathway (SMF → reduced flow → anoxia → ECG changes) is proposed based on simulations; empirical confirmation details not provided in the abstract

Suggested hubs

• mri-static-fields (0.9)
  Focuses on ultrahigh static magnetic fields with explicit mention of MRI scanning and ECG safety inspection.

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    "outcomes": [
        "ECG T-wave alternation",
        "T-wave amplitude",
        "blood volume flow rate in aorta",
        "anoxia/acute ischemia (modeled)",
        "ventricular action potential plateau suppression",
        "action potential duration shortening"
    ],
    "main_findings": "A magneto-hydrodynamics model suggested that ultrahigh static magnetic fields could reduce blood volume flow rate in the human aorta by more than 10%, which the authors propose may lead to an anoxia condition of acute ischemia. Using an ionic-based ventricular cell model, simulations indicated that anoxia could increase T-wave amplitude and was presented as a possible mechanism contributing to T-wave effects observed under ultrahigh static magnetic fields.",
    "effect_direction": "harm",
    "limitations": [
        "Modeling study (magneto-hydrodynamics and theoretical ionic-based cell simulations) rather than direct human or animal exposure measurements",
        "Exposure level described as 'ultrahigh' static magnetic field without quantitative field strength in the abstract",
        "Causal pathway (SMF → reduced flow → anoxia → ECG changes) is proposed based on simulations; empirical confirmation details not provided in the abstract"
    ],
    "evidence_strength": "very_low",
    "confidence": 0.66000000000000003108624468950438313186168670654296875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "static magnetic field",
        "ultrahigh SMF",
        "MRI",
        "ECG",
        "T-wave alternation",
        "T-wave amplitude",
        "magneto-hydrodynamics",
        "aorta blood flow",
        "anoxia",
        "ischemia",
        "ventricular cell model",
        "action potential duration"
    ],
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