Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with

PAPER manual Frontiers in Network Physiology 2024 Review Effect: benefit Evidence: Insufficient

Read original paper → DOI: 10.3389/fnetp.2024.1483401 Evidence Lab

Abstract

Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body – a comprehensive review Costa FP, Wiedenmann B, Schöll E, Tuszynski J. Emerging cancer therapies: targeting physiological networks and cellular bioelectrical differences with non-thermal systemic electromagnetic fields in the human body – a comprehensive review. Frontiers in Network Physiology. Vol. 4, 2024. doi: 10.3389/fnetp.2024.1483401. Abstract A steadily increasing number of publications support the concept of physiological networks, and how cellular bioelectrical properties drive cell proliferation and cell synchronization. All cells, especially cancer cells, are known to possess characteristic electrical properties critical for physiological behavior, with major differences between normal and cancer cell counterparts. This opportunity can be explored as a novel treatment modality in Oncology. Cancer cells exhibit autonomous oscillations, deviating from normal rhythms. In this context, a shift from a static view of cellular processes is required for a better understanding of the dynamic connections between cellular metabolism, gene expression, cell signaling and membrane polarization as states in constant flux in realistic human models. In oncology, radiofrequency electromagnetic fields have produced sustained responses and improved quality of life in cancer patients with minimal side effects. This review aims to show how non-thermal systemic radiofrequency electromagnetic fields leads to promising therapeutic responses at cellular and tissue levels in humans, supporting this newly emerging cancer treatment modality with early favorable clinical experience specifically in advanced cancer. Open access paper: frontiersin.org

AI evidence extraction

At a glance

Study type

Review

Effect direction

benefit

Population

Humans (cancer patients; advanced cancer mentioned)

Sample size

—

Exposure

Evidence strength

Insufficient

Confidence: 66% · Peer-reviewed: yes

Main findings

The review states that in oncology, radiofrequency electromagnetic fields have produced sustained responses and improved quality of life in cancer patients with minimal side effects, and argues that non-thermal systemic RF fields show promising therapeutic responses at cellular and tissue levels in humans, with early favorable clinical experience in advanced cancer.

Outcomes measured

Therapeutic response (sustained responses)
Quality of life
Side effects (minimal side effects reported)
Cellular and tissue-level responses

Limitations

No specific frequencies, dosimetry (e.g., SAR), or exposure durations are provided in the abstract.
No specific clinical study designs, sample sizes, or quantitative effect estimates are described in the abstract.
Claims are presented as a narrative synthesis; strength of underlying evidence cannot be assessed from the abstract alone.

View raw extracted JSON

{
    "study_type": "review",
    "exposure": {
        "band": "RF",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Humans (cancer patients; advanced cancer mentioned)",
    "sample_size": null,
    "outcomes": [
        "Therapeutic response (sustained responses)",
        "Quality of life",
        "Side effects (minimal side effects reported)",
        "Cellular and tissue-level responses"
    ],
    "main_findings": "The review states that in oncology, radiofrequency electromagnetic fields have produced sustained responses and improved quality of life in cancer patients with minimal side effects, and argues that non-thermal systemic RF fields show promising therapeutic responses at cellular and tissue levels in humans, with early favorable clinical experience in advanced cancer.",
    "effect_direction": "benefit",
    "limitations": [
        "No specific frequencies, dosimetry (e.g., SAR), or exposure durations are provided in the abstract.",
        "No specific clinical study designs, sample sizes, or quantitative effect estimates are described in the abstract.",
        "Claims are presented as a narrative synthesis; strength of underlying evidence cannot be assessed from the abstract alone."
    ],
    "evidence_strength": "insufficient",
    "confidence": 0.66000000000000003108624468950438313186168670654296875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "cancer therapy",
        "oncology",
        "physiological networks",
        "bioelectrical properties",
        "membrane polarization",
        "non-thermal",
        "systemic electromagnetic fields",
        "radiofrequency electromagnetic fields",
        "quality of life"
    ],
    "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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