Magnetic Fields and Reactive Oxygen Species

Abstract

Magnetic Fields and Reactive Oxygen Species Wang H, Zhang X. Magnetic Fields and Reactive Oxygen Species. Int J Mol Sci. 2017 Oct 18;18(10). pii: E2175. doi: 10.3390/ijms18102175 Abstract Reactive oxygen species (ROS) ubiquitously exist in mammalian cells to participate in various cellular signaling pathways. The intracellular ROS levels are dependent on the dynamic balance between ROS generation and elimination. In this review, we summarize reported studies about the influences of magnetic fields (MFs) on ROS levels. Although in most cases, MFs increased ROS levels in human, mouse, rat cells, and tissues, there are also studies showing that ROS levels were decreased or not affected by MFs. Multiple factors could cause these discrepancies, including but not limited to MF type/intensity/frequency, exposure time and assay time-point, as well as different biological samples examined. It will be necessary to investigate the influences of different MFs on ROS in various biological samples systematically and mechanistically, which will be helpful for people to get a more complete understanding about MF-induced biological effects. In addition, reviewing the roles of MFs in ROS modulation may open up new scenarios of MF application, which could be further and more widely adopted into clinical applications, particularly in diseases that ROS have documented pathophysiological roles. Open Access Paper: mdpi.com

AI evidence extraction

Main findings

This review summarizes reported studies on the influence of magnetic fields (MFs) on intracellular ROS levels. It reports that in most cases MFs increased ROS levels in human, mouse, and rat cells and tissues, but some studies found decreased ROS levels or no effect; discrepancies are attributed to differences in MF type/intensity/frequency, exposure time, assay time-point, and biological samples.

Outcomes measured

• reactive oxygen species (ROS) levels

Limitations

• Discrepant findings across studies, potentially due to differences in MF type/intensity/frequency, exposure time, assay time-point, and biological samples examined.
• Calls for more systematic and mechanistic investigation across different magnetic fields and biological samples.

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    "outcomes": [
        "reactive oxygen species (ROS) levels"
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    "main_findings": "This review summarizes reported studies on the influence of magnetic fields (MFs) on intracellular ROS levels. It reports that in most cases MFs increased ROS levels in human, mouse, and rat cells and tissues, but some studies found decreased ROS levels or no effect; discrepancies are attributed to differences in MF type/intensity/frequency, exposure time, assay time-point, and biological samples.",
    "effect_direction": "mixed",
    "limitations": [
        "Discrepant findings across studies, potentially due to differences in MF type/intensity/frequency, exposure time, assay time-point, and biological samples examined.",
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        "magnetic fields",
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