Oxidative stress-mediated alterations on sperm parameters in male Wistar rats exposed to 3G mobile phone radiation

PAPER manual 2019 Animal study Effect: harm Evidence: Low

Read original paper → DOI: 10.1111/and.13201 Evidence Lab

Abstract

Oxidative stress-mediated alterations on sperm parameters in male Wistar rats exposed to 3G mobile phone radiation Gautam R, Singh KV, Nirala J, Murmu NN, Meena R, Rajamani P. Oxidative stress-mediated alterations on sperm parameters in male Wistar rats exposed to 3G mobile phone radiation. Andrologia. 2019 Apr;51(3):e13201. doi: 10.1111/and.13201. Abstract In recent years, there has been significant increase in mobile phone users. With this, health concerns associated with the exposure to electromagnetic radiation are also increasing. Continuous exposure to electromagnetic (EM) radiation generated from mobile phone is one of the probable reasons behind increasing male infertility. EM radiations induce oxidative stress that leads to numerous changes in reproductive parameters. With this hypothesis, we studied the effect of 3G mobile phone radiations on the reproductive system of male Wistar rats. Adult rats were divided into two groups: control and radio frequency-exposed. The animals were exposed to 3G mobile phone radiation for 45 days (2 hr/day) in specially designed exposure setup under standard conditions. Various biochemical and physiological parameters such as sperm count, sperm morphology, mitochondrial activity, lipid peroxidation, reactive oxygen species level and histopathological analysis were studied. Histopathological examination revealed a reduction in spermatogenic cells and alterations in sperm membrane. Significant increase in ROS and lipid peroxidation level with simultaneously decrease in sperm count, alterations in sperm tail morphology were observed in the exposed group. In conclusion, exposure to mobile phone radiations induces oxidative stress in male Wistar rats which may lead to alteration in sperm parameters and affects their fertility. ncbi.nlm.nih.gov

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Adult male Wistar rats

Sample size

—

Exposure

RF mobile phone · 45 days (2 hr/day)

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

Compared with controls, the radiofrequency-exposed group showed increased ROS and lipid peroxidation along with decreased sperm count and alterations in sperm tail morphology. Histopathology indicated reduced spermatogenic cells and alterations in sperm membrane in exposed rats.

Outcomes measured

sperm count
sperm morphology
mitochondrial activity
lipid peroxidation
reactive oxygen species (ROS) level
histopathology of reproductive tissue/spermatogenic cells
sperm membrane alterations

Limitations

Sample size not reported in abstract
Exposure frequency and SAR not reported in abstract
Only two groups described; randomization/blinding not stated
Animal model; generalizability to humans not addressed in abstract

Suggested hubs

mobile-phones (0.9)
Study examines effects of 3G mobile phone radiation exposure.
male-fertility (0.85)
Outcomes include sperm count/morphology and fertility-related parameters.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": "mobile phone",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "45 days (2 hr/day)"
    },
    "population": "Adult male Wistar rats",
    "sample_size": null,
    "outcomes": [
        "sperm count",
        "sperm morphology",
        "mitochondrial activity",
        "lipid peroxidation",
        "reactive oxygen species (ROS) level",
        "histopathology of reproductive tissue/spermatogenic cells",
        "sperm membrane alterations"
    ],
    "main_findings": "Compared with controls, the radiofrequency-exposed group showed increased ROS and lipid peroxidation along with decreased sperm count and alterations in sperm tail morphology. Histopathology indicated reduced spermatogenic cells and alterations in sperm membrane in exposed rats.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in abstract",
        "Exposure frequency and SAR not reported in abstract",
        "Only two groups described; randomization/blinding not stated",
        "Animal model; generalizability to humans not addressed in abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "3G",
        "mobile phone radiation",
        "radiofrequency",
        "Wistar rats",
        "male fertility",
        "sperm parameters",
        "oxidative stress",
        "ROS",
        "lipid peroxidation",
        "histopathology"
    ],
    "suggested_hubs": [
        {
            "slug": "mobile-phones",
            "weight": 0.90000000000000002220446049250313080847263336181640625,
            "reason": "Study examines effects of 3G mobile phone radiation exposure."
        },
        {
            "slug": "male-fertility",
            "weight": 0.84999999999999997779553950749686919152736663818359375,
            "reason": "Outcomes include sperm count/morphology and fertility-related parameters."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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