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Doxorubicin-induced cardiotoxicity under 28 GHz 5G-band electromagnetic radiation in rats: Insights into the mitigative role of vitamin C
This animal study tested whether short-term 28 GHz (5G-band) millimeter-wave exposure modifies doxorubicin-induced cardiotoxicity in male rats and whether vitamin C mitigates effects. Co-exposure to 28 GHz EMR was reported to worsen several indices of DOX-related cardiac injury (including CAT reduction, increased BAX expression, and QT prolongation), while vitamin C provided partial attenuation. The authors emphasize that results are limited to a short-duration preclinical model and that human relevance remains preliminary.
The International Collaborative Animal Study of Mobile Phone Radiofrequency Radiation Carcinogenicity and Genotoxicity: The Japanese Study
This international collaborative animal study (Japanese arm) evaluated carcinogenicity and genotoxicity in male Sprague Dawley rats exposed long-term to 900 MHz CDMA-modulated RF-EMFs at 4 W/kg whole-body SAR. The abstract reports no statistically significant increases in neoplastic or non-neoplastic lesions in major organs and no evidence of genotoxicity on comet or micronucleus testing. The authors conclude the findings provide strong evidence of no reproducible carcinogenic or genotoxic effects under the studied conditions.
Male Reproductive and Cellular Damage After Prenatal 3.5 GHz Radiation Exposure: One-Year Postnatal Effects
This animal study examined whether prenatal exposure to 3.5 GHz radiofrequency radiation (2 hours/day) affects male reproductive outcomes later in life. Male rat offspring assessed at 12 months showed multiple adverse testicular and cellular findings in exposed groups versus sham controls, including impaired spermatogenesis markers, increased abnormal sperm morphology, increased DNA damage, and increased apoptosis, with full-gestation exposure generally most pronounced. The authors interpret the results as evidence of persistent reproductive toxicity from prenatal exposure and call for further mechanistic work and precautionary actions.
The effect of alpha-lipoic acid on liver damage induced by extremely low-frequency electromagnetic fields in a rat model
This rat study assessed whether alpha-lipoic acid (ALA) modifies liver effects from extremely low-frequency magnetic field (ELF-MF) exposure. ELF-MF exposure (2 mT, 4 hours/day for 30 days) was associated with increased liver pathology and higher apoptosis markers (TUNEL, caspase-3) compared with other groups. ALA reduced several histopathological changes and lowered TUNEL/caspase-3, but did not improve fibrosis or biliary proliferation.
Effects of coenzyme Q10 on sperm parameters and pathological changes induced by Wi-Fi waves in the testicular tissue of rats
This animal study exposed rats to Wi‑Fi waves for 7 hours/day for 2 months and assessed sperm parameters, serum testosterone, and testicular/epididymal pathology, with and without coenzyme Q10 (CoQ10). The authors report that Wi‑Fi exposure was linked to worse sperm parameters, lower testosterone, and adverse testicular pathology. CoQ10 supplementation during exposure was reported to mitigate these changes compared with Wi‑Fi exposure alone.
The effect on rat peripheral nerve morphology and function of a 900-MHz electromagnetic field applied in the prenatal period
This animal study exposed pregnant Sprague Dawley rats to a 900 MHz electromagnetic field for 1 hour daily throughout gestation and assessed offspring outcomes postnatally. Sciatic nerve analyses at postnatal day 60 indicated persistent morphological alterations attributed to prenatal EMF exposure. However, the reported changes were not severe enough to significantly affect measured functional outcomes (including electrophysiology and locomotor tests).