Doxorubicin-induced cardiotoxicity under 28 GHz 5G-band electromagnetic radiation in rats: Insights into the mitigative role of vitamin C
This animal study tested whether short-term 28 GHz (5G-band) millimeter-wave exposure modifies doxorubicin-induced cardiotoxicity in male rats and whether vitamin C mitigates effects. Co-exposure to 28 GHz EMR was reported to worsen several indices of DOX-related cardiac injury (including CAT reduction, increased BAX expression, and QT prolongation), while vitamin C provided partial attenuation. The authors emphasize that results are limited to a short-duration preclinical model and that human relevance remains preliminary.
Key points
- Thirty male Sprague-Dawley rats were allocated to five groups (n=6 each), including DOX-only and DOX+28 GHz EMR conditions.
- EMR exposure was 28 GHz for three 10-minute cycles per day over 14 days, with a reported peak local SAR of 7.62 W/kg.
- Doxorubicin produced functional, biochemical, molecular, and structural signs of cardiotoxicity across multiple endpoints.
- Co-exposure to 28 GHz EMR amplified reductions in catalase (CAT) and increased pro-apoptotic BAX gene expression compared with DOX alone.
- QT interval prolongation was reported in the DOX+28 GHz EMR group relative to DOX alone.
- Vitamin C (250 mg/kg orally for 14 days) provided partial protection across assessed endpoints in this model.
- The authors frame the findings as hypothesis-generating and call for longer-term and clinical studies to clarify mechanisms and relevance.
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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